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Immune Alterations in a Patient with SARS-CoV-2-Related Acute Respiratory Distress Syndrome

dc.rights.licenseopenen_US
dc.contributor.authorBOUADMA, L.
dc.contributor.authorWIEDEMANN, A.
dc.contributor.authorPATRIER, J.
dc.contributor.authorSURENAUD, M.
dc.contributor.authorWICKY, P. H.
dc.contributor.authorFOUCAT, E.
dc.contributor.authorDIEHL, J. L.
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHEJBLUM, Boris
ORCID: 0000-0003-0646-452X
IDREF: 189970316
dc.contributor.authorSINNAH, F.
dc.contributor.authorDE MONTMOLLIN, E.
dc.contributor.authorLACABARATZ, C.
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTHIEBAUT, Rodolphe
dc.contributor.authorTIMSIT, J. F.
dc.contributor.authorLEVY, Y.
dc.date.accessioned2021-01-18T10:57:49Z
dc.date.available2021-01-18T10:57:49Z
dc.date.issued2020
dc.identifier.issn1573-2592 (Electronic) 0271-9142 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/25812
dc.description.abstractEnWe report a longitudinal analysis of the immune response associated with a fatal case of COVID-19 in Europe. This patient exhibited a rapid evolution towards multiorgan failure. SARS-CoV-2 was detected in multiple nasopharyngeal, blood, and pleural samples, despite antiviral and immunomodulator treatment. Clinical evolution in the blood was marked by an increase (2–3-fold) in differentiated effector T cells expressing exhaustion (PD-1) and senescence (CD57) markers, an expansion of antibody-secreting cells, a 15-fold increase in γδ T cell and proliferating NK-cell populations, and the total disappearance of monocytes, suggesting lung trafficking. In the serum, waves of a pro-inflammatory cytokine storm, Th1 and Th2 activation, and markers of T cell exhaustion, apoptosis, cell cytotoxicity, and endothelial activation were observed until the fatal outcome. This case underscores the need for well-designed studies to investigate complementary approaches to control viral replication, the source of the hyperinflammatory status, and immunomodulation to target the pathophysiological response. The investigation was conducted as part of an overall French clinical cohort assessing patients with COVID-19 and registered in clinicaltrials.gov under the following number: NCT04262921.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectSISTM
dc.title.enImmune Alterations in a Patient with SARS-CoV-2-Related Acute Respiratory Distress Syndrome
dc.title.alternativeJ Clin Immunolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s10875-020-00839-x
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32829467en_US
bordeaux.journalJournal of Clinical Immunologyen_US
bordeaux.page1082-1092en_US
bordeaux.volume40en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue8en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSISTM_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03160737
hal.version1
hal.date.transferred2021-03-23T09:56:04Z
hal.exporttrue
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