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Pharmacological treatment patterns in heart failure: a population-based cohort study

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBOSCO-LEVY, Pauline
dc.contributor.authorFAVARY, C.
dc.contributor.authorJOVE, J.
dc.contributor.authorLASSALLE, R.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMOORE, Nicholas
dc.contributor.authorDROZ-PERROTEAU, C.
dc.date.accessioned2021-01-18T10:53:14Z
dc.date.available2021-01-18T10:53:14Z
dc.date.issued2020
dc.identifier.issn0031-6970en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/25811
dc.description.abstractEnBackground Although the efficacy and safety of existing therapies of heart failure (HF) have been demonstrated in clinical trials, little is known about the treatment patterns in clinical practice, especially in France. Objectives To describe the treatment initiation patterns and the subsequent treatment changes among HF patients, in the first year following an incident hospitalization for HF, in a French real-world setting. Methods A cohort of patients aged ≥ 40 years, with an incident hospitalization for HF between 01/01/2008 and 31/12/2013, was identified in the 1/97th permanent random sample of the French nationwide claims database and followed 1 year. HF drug exposure—beta blockers (BB), angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARBs), aldosterone antagonists (AA), diuretics, digoxin, or ivabradine—was assessed quarterly using a Proportion of Days Covered ≥ 66% (≥ 60 days out of the 90 days of the quarter), by considering HF drugs individually or in combination. Drug changes were assessed between each quarter. Results Between 2008 and 2013, 7387 patients were included. Their mean age was 77.7 years (± 12.0 years) and 51.6% were women. During the follow-up, 24.4% died, 20% were not exposed to any HF treatment, 48.3 to 43.2% had diuretics, one third had BB or ACEI, 9% had ARB or AA, 6% had digoxin, and 2% had ivabradine. The main change occurred between the first and the second quarter for 53.1% of the initially untreated patients. Conclusion This study provides valuable information on treatment patterns after an initial hospitalization for HF.
dc.language.isoENen_US
dc.subjectPharmacoEpi-Drugs
dc.title.enPharmacological treatment patterns in heart failure: a population-based cohort study
dc.title.alternativeEur J Clin Pharmacolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s00228-019-02758-2en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31637454en_US
bordeaux.journalEur J Clin Pharmacolen_US
bordeaux.page97-106en_US
bordeaux.volume76en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamPharmacoEpi-Drugsen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03113306
hal.version1
hal.date.transferred2021-01-18T10:53:19Z
hal.exporttrue
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