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Association Between Frailty and HIV-Associated Neurodegenerative Disorders Among Older Adults Living with HIV

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorZAMUDIO RODRIGUEZ, Alfonso
dc.contributor.authorBELAUNZARAN-ZAMUDIO, P. F.
dc.contributor.authorSIERRA-MADERO, J. G.
dc.contributor.authorCUELLAR-RODRIGUEZ, J.
dc.contributor.authorCRABTREE-RAMIREZ, B. E.
dc.contributor.authorALCALA-ZERMENO, J. L.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorAMIEVA, Helene
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorAVILA-FUNES, Jose Alberto
dc.date.accessioned2021-01-07T11:14:55Z
dc.date.available2021-01-07T11:14:55Z
dc.date.issued2018-05
dc.identifier.issn1931-8405 (Electronic) 0889-2229 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/23735
dc.description.abstractEnINTRODUCTION: The population of aging adults living with Human Immunodeficiency Virus (HIV) is growing worldwide and evidence suggests that frailty occurs prematurely among them. In turn, frailty has been associated with cognitive decline. It is unknown, however, if people with both frailty and HIV-infection have higher risk of cognitive impairment compared with non-frail HIV-infected persons. Therefore, the main objective of this study was to determine the association between the phenotype of frailty and HIV-associated neurocognitive disorders (HAND) among adults aged 50 years or older living with HIV/AIDS. MATERIAL AND METHODS: A cross-sectional study was conducted on 206 adults living with HIV receiving care in a university-affiliated tertiary care hospital in Mexico City. Frailty was defined as per the Fried criteria. The presence of HAND was established according to the Antinori criteria: HIV-associated asymptomatic neurocognitive impairment (ANI), HIV-associated mild neurocognitive disorder (MND), or cognitively non-impaired. Multinomial logistic regression models were used to test the independent association between frailty and HAND adjusting for potential confounders. RESULTS: Mean age of participants was 60.5 +/- 6.3 years and 84.9% were male. Prevalence of HAND and frailty phenotype was 66.0% and 2.9 %, respectively. The unadjusted analysis showed that both prefrail and frail statuses were associated with MND but not with ANI. However, after adjustment, the association with MND remained significant only among prefrail participants and no longer for frail persons (RR = 5.7, 95% CI 1.09 to 29.82; p = .039 and RR = 18.3, 95% CI 0.93 to 362.6; p = .056, respectively). DISCUSSION: Prefrailty is associated with symptomatic neurocognitive disorders in older adults living with HIV. The spectrum of the frailty phenotype in this already vulnerable population should serve as an indicator of concomitant cognitive decline.
dc.language.isoENen_US
dc.subject.enSEPIA
dc.title.enAssociation Between Frailty and HIV-Associated Neurodegenerative Disorders Among Older Adults Living with HIV
dc.title.alternativeAIDS Res Hum Retrovirusesen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1089/aid.2017.0100en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29385834en_US
bordeaux.journalAIDS Research and Human Retrovirusesen_US
bordeaux.page449-455en_US
bordeaux.volume34en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSEPIAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03193144
hal.version1
hal.date.transferred2021-04-08T13:36:41Z
hal.exporttrue
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=AIDS%20Research%20and%20Human%20Retroviruses&rft.date=2018-05&rft.volume=34&rft.issue=5&rft.spage=449-455&rft.epage=449-455&rft.eissn=1931-8405%20(Electronic)%200889-2229%20(Linking)&rft.issn=1931-8405%20(Electronic)%200889-2229%20(Linking)&rft.au=ZAMUDIO%20RODRIGUEZ,%20Alfonso&BELAUNZARAN-ZAMUDIO,%20P.%20F.&SIERRA-MADERO,%20J.%20G.&CUELLAR-RODRIGUEZ,%20J.&CRABTREE-RAMIREZ,%20B.%20E.&rft.genre=article


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