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Effect of SSRI and calcium channel blockers on depression symptoms and cognitive function in elderly persons treated for hypertension: three city cohort study

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTULLY, Phillip J.
dc.contributor.authorPETERS, R.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPERES, Karine
ORCID: 0000-0002-0720-0684
IDREF: 080634001
dc.contributor.authorANSTEY, K. J.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTZOURIO, Christophe
IDREF: 69829209
dc.date.accessioned2021-01-06T10:17:20Z
dc.date.available2021-01-06T10:17:20Z
dc.date.issued2018-09
dc.identifier.issn1741-203X (Electronic) 1041-6102 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/23691
dc.description.abstractEnBACKGROUND: Emerging genetic, ex-vivo, and clinical trial evidence indicates that calcium channel blockers (CCB) can improve mood and cognitive function. The objective of this study was to examine the effect of selective serotonin reuptake inhibitor (SSRI) therapy augmented with CCB on depression and cognitive decline in an elderly population with hypertension. METHODS: Prospective study of 296 persons treated with SSRI and antihypertensive drugs. Baseline and two year clinic assessments were used to categorize participants as users of SSRI + CCB (n = 53) or users of SSRI + other antihypertensives (n = 243). Clinic visits were performed up to four times in a ten-year period to assess depression and cognitive function. RESULTS: The sample mean age was 75.2 +/- 5.47 years and 78% of participants were female. At two year follow-up there was a significant group by time interaction showing lower Center for Epidemiological Studies-Depression (CESD) scores in the SSRI + CCB group, F(1,291) = 4.13, p = 0.043, eta2 p = 0.014. Over ten-years follow-up, SSRI + CCB use was associated with improved general cognitive function (Mini-Mental State Examination: beta = 0.97; 95% CI 0.14 to 1.81, p = 0.023) and immediate visual memory (Boston Visual Retention Test: beta = 0.69; 95% CI 0.06 to 1.32, p = 0.033). CONCLUSION: The findings provide general population evidence that SSRI augmentation with CCB may improve depression and cognitive function.
dc.language.isoENen_US
dc.subject.enHEALTHY
dc.subject.enSEPIA
dc.subject.enVINTAGE
dc.title.enEffect of SSRI and calcium channel blockers on depression symptoms and cognitive function in elderly persons treated for hypertension: three city cohort study
dc.title.alternativeInt Psychogeriatren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1017/s1041610217002903en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29559030en_US
bordeaux.journalInternational Psychogeriatricsen_US
bordeaux.page1345-1354en_US
bordeaux.volume30en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamHEALTHY_BPHen_US
bordeaux.teamSEPIAen_US
bordeaux.teamVINTAGEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03194242
hal.version1
hal.date.transferred2021-04-09T12:02:03Z
hal.exporttrue
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