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Fish Intake, Genetic Predisposition to Alzheimer Disease, and Decline in Global Cognition and Memory in 5 Cohorts of Older Persons

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIERI, Cecilia
dc.contributor.authorMORRIS, M. C.
dc.contributor.authorBENNETT, D. A.
dc.contributor.authorBERR, C.
dc.contributor.authorAMOUYEL, Philippe
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTZOURIO, Christophe
dc.contributor.authorCHASMAN, D. I.
dc.contributor.authorGRODSTEIN, F.
dc.date.accessioned2021-01-04T15:16:55Z
dc.date.available2021-01-04T15:16:55Z
dc.date.issued2018-05-01
dc.identifier.issn1476-6256 (Electronic) 0002-9262 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/23630
dc.description.abstractEnFish are a primary source of long-chain omega-3 fatty acids, which may help delay cognitive aging. We pooled participants from the French Three-City study and four US cohorts (Nurses' Health Study, Women's Health Study, Chicago Health and Aging Project and Rush Memory and Aging Project) with diet and cognitive data (n = 23,688 Caucasians aged >/=65 years, 88% female, baseline year range, 1992-1999, median follow-up range, 3.9-9.1 years) to investigate the relation of fish intake to cognitive decline and examine interactions with Alzheimer's disease-related genes. We estimated cohort-specific associations between fish and change in composite scores of global cognition and episodic memory using linear mixed models, and pooled results using inverse-variance weighted meta-analysis. In multivariate analyses, higher fish intake was associated with slower decline in both global cognition and memory (P-trend </= 0.031). Consuming >/=4 versus <1 fish serving/week was associated with 0.018 (95% CI: 0.004, 0.032) standard units lower rate of memory decline; an effect estimate equivalent to that found for 4 years of age. For global cognition, no comparisons of higher versus low fish intake reached statistical significance. In this meta-analysis, increasing fish intake was associated with decreasing memory decline. We found no evidence of effect modification by Alzheimer's disease genes.
dc.language.isoENen_US
dc.subject.enLEHA
dc.subject.enSEPIA
dc.subject.enVINTAGE
dc.title.enFish Intake, Genetic Predisposition to Alzheimer Disease, and Decline in Global Cognition and Memory in 5 Cohorts of Older Persons
dc.title.alternativeAm J Epidemiolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/aje/kwx330en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29053784en_US
bordeaux.journalAmerican journal of epidemiologyen_US
bordeaux.page933-940en_US
bordeaux.volume187en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamLEHA_BPH
bordeaux.teamSEPIAen_US
bordeaux.teamVINTAGEen_US
bordeaux.teamHEALTHY_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=American%20journal%20of%20epidemiology&amp;rft.date=2018-05-01&amp;rft.volume=187&amp;rft.issue=5&amp;rft.spage=933-940&amp;rft.epage=933-940&amp;rft.eissn=1476-6256%20(Electronic)%200002-9262%20(Linking)&amp;rft.issn=1476-6256%20(Electronic)%200002-9262%20(Linking)&amp;rft.au=SAMIERI,%20Cecilia&amp;MORRIS,%20M.%20C.&amp;BENNETT,%20D.%20A.&amp;BERR,%20C.&amp;AMOUYEL,%20Philippe&amp;rft.genre=article


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