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Tissue-resident NK cells differ in their expression profile of the nutrient transporters Glut1, CD98 and CD71

dc.rights.licenseopenen_US
dc.contributor.authorSALZBERGER, W.
dc.contributor.authorMARTRUS, G.
dc.contributor.authorBACHMANN, K.
dc.contributor.authorGOEBELS, H.
dc.contributor.authorHESS, L.
dc.contributor.authorKOCH, M.
dc.contributor.authorLANGENECKERT, A.
dc.contributor.authorLUNEMANN, S.
dc.contributor.authorOLDHAFER, K. J.
dc.contributor.authorPFEIFER, C.
dc.contributor.authorPOCH, T.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRICHERT, Laura
dc.contributor.authorSCHRAMM, C.
dc.contributor.authorWAHIB, R.
dc.contributor.authorBUNDERS, M. J.
dc.contributor.authorALTFELD, M.
dc.date.accessioned2021-01-04T14:42:04Z
dc.date.available2021-01-04T14:42:04Z
dc.date.issued2018-07-22
dc.identifier.issn1932-6203 (Electronic) 1932-6203 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/23626
dc.description.abstractEnMetabolism is a critical basis for immune cell functionality. It was recently shown that NK cell subsets from peripheral blood modulate their expression of nutrient receptors following cytokine stimulation, demonstrating that NK cells can adjust to changes in metabolic requirements. As nutrient availability in blood and tissues can significantly differ, we examined NK cells isolated from paired blood-liver and blood-spleen samples and compared expression of the nutrient transporters Glut1, CD98 and CD71. CD56bright tissue-resident (CXCR6+) NK cells derived from livers and spleens expressed lower levels of Glut1 but higher levels of the amino acid transporter CD98 following stimulation than CD56bright NK cells from peripheral blood. In line with that, CD56dim NK cells, which constitute the main NK cell population in the peripheral blood, expressed higher levels of Glut1 and lower levels of CD98 and CD71 compared to liver CD56bright NK cells. Our results show that NK cells from peripheral blood differ from liver- and spleen-resident NK cells in the expression profile of nutrient transporters, consistent with a cell-adaptation to the different nutritional environment in these compartments.
dc.language.isoENen_US
dc.subject.enSISTM
dc.title.enTissue-resident NK cells differ in their expression profile of the nutrient transporters Glut1, CD98 and CD71
dc.title.alternativePLoS Oneen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1371/journal.pone.0201170en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30028872en_US
bordeaux.journalPLoS ONEen_US
bordeaux.pagee0201170en_US
bordeaux.volume13en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSISTMen_US
bordeaux.teamSISTM_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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