Associations between serum albumin and serious non-AIDS events among people living with HIV
| dc.rights.license | open | en_US |
| dc.contributor.author | RONIT, A. | |
| dc.contributor.author | HATLEBERG, C. I. | |
| dc.contributor.author | RYOM, L. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BONNET, Fabrice | |
| dc.contributor.author | EL-SADR, W. | |
| dc.contributor.author | REISS, P. | |
| dc.contributor.author | WEBER, R. | |
| dc.contributor.author | PRADIER, C. | |
| dc.contributor.author | DE WIT, S. | |
| dc.contributor.author | LAW, M. | |
| dc.contributor.author | D'ARMINIO MONFORTE, A. | |
| dc.contributor.author | LUNDGREN, J. | |
| dc.contributor.author | MOCROFT, A. | |
| dc.contributor.author | PHILLIPS, A. N. | |
| dc.contributor.author | SABIN, C. A. | |
| dc.date.accessioned | 2021-01-04T10:38:16Z | |
| dc.date.available | 2021-01-04T10:38:16Z | |
| dc.date.issued | 2018-08-24 | |
| dc.identifier.issn | 1473-5571 (Electronic) 0269-9370 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/23610 | |
| dc.description.abstractEn | OBJECTIVE: Lower serum albumin (sAlb) has been associated with an increased risk of mortality and AIDS among people living with HIV and may be associated with the development of serious non-AIDS events (SNAEs). We evaluated the long-term association between sAlb and the risk of SNAEs. DESIGN: Prospective multinational cohort study. METHODS: D:A:D participants without SNAEs were followed from first routine sAlb value to the first of a new SNAE [cardiovascular disease (CVD), end-stage liver disease (ESLD), end-stage renal disease (ESRD), non-AIDS malignancy (NADM), death from non-AIDS cause], AIDS-death, 6 months after last visit or 1 February 2016. Poisson regression was used to determine associations between sAlb and a new SNAE, CVD, or NADM event, with adjustment for potential confounders. Models additionally tested whether the associations were modified by age, follow-up time, smoking status, CD4 and viral load. RESULTS: Of 16 350 participants (71.8% male, median age 44 years), 1463 developed an SNAE (371 CVD, 200 ESLD, 40 ESRD, 553 NADM, 299 deaths from other non-AIDS causes) over 80 264 person-years. Increased sAlb was associated with a decreased risk of an SNAE [adjusted rate ratio per 5 g/l: SNAE 0.79 (95% confidence interval: 0.76, 0.83); CVD 0.87 (0.80, 0.94); NADM 0.88 (0.82, 0.95)]. The association did not appear to wane with additional years of follow-up (P-interaction = 0.79) but was stronger for current smokers than for never smokers (P-interaction <0.01). CONCLUSION: sAlb is a durable risk factor for SNAE. Future studies are needed to determine the mechanism underlying this association and to evaluate the value of sAlb in predictive tools. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | MORPH3Eus | |
| dc.subject.en | DAD | |
| dc.title.en | Associations between serum albumin and serious non-AIDS events among people living with HIV | |
| dc.title.alternative | AIDS | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1097/qad.0000000000001900 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 29847331 | en_US |
| bordeaux.journal | AIDS. Official journal of the international AIDS Society | en_US |
| bordeaux.page | 1837-1848 | en_US |
| bordeaux.volume | 32 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 13 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | MORPH3Eus | en_US |
| bordeaux.team | DAD | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03194223 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-04-09T11:52:26Z | |
| hal.export | true | |
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