Association of Childhood Irritability and Depressive/Anxious Mood Profiles With Adolescent Suicidal Ideation and Attempts
dc.rights.license | open | en_US |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | ORRI, Massimiliano | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | GALERA, Cedric
ORCID: 0000-0003-0549-9608 IDREF: 110034007 | |
dc.contributor.author | TURECKI, Gustavo | |
dc.contributor.author | FORTE, Alberto | |
dc.contributor.author | RENAUD, Johanne | |
dc.contributor.author | BOIVIN, Michel | |
dc.contributor.author | TREMBLAY, Richard | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | COTE, Sylvana
ORCID: 0000-0001-7944-0647 | |
dc.contributor.author | GEOFFROY, Marie Claude | |
dc.date.accessioned | 2020-12-14T09:11:27Z | |
dc.date.available | 2020-12-14T09:11:27Z | |
dc.date.issued | 2018-05-01 | |
dc.identifier.issn | 2168-6238 (Electronic) 2168-622X (Linking) | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/21424 | |
dc.description.abstractEn | Importance: Suicidal ideation and suicide attempt (suicidality) are common in adolescence and a public health concern. Childhood depression is a key risk factor for later suicidality and often co-occurs with irritability. No study to date has examined the joint association of depressive mood and irritability during childhood with later suicidality. Objective: To investigate the association of childhood irritability and depressive/anxious mood profiles with adolescent suicidality. Design, Setting, and Participants: This population-based cohort study included 1430 participants in the Quebec Longitudinal Study of Child Development. Participants underwent assessment yearly or bi-yearly (5 months to 17 years). Data were collected from March 16, 1998, through July 17, 2015. Exposures: Profiles defined by the joint developmental trajectories of irritability and depressive/anxious mood at 6 to 12 years of age. Main Outcomes and Measures: Self-reported past-year suicidality (ie, serious suicidal ideation or suicide attempt) at 13, 15, and 17 years of age. Irritability and depressive/anxious mood were assessed using teacher report 5 times from 6 to 12 years of age. Results: The study included 1430 participants (676 boys [47.3%] and 754 girls [52.7%]) followed up to 17 years of age. Group-based multitrajectory modeling identified the following profiles: combined no irritability and low depressive/anxious mood with low irritability and low depressive/anxious mood (831 [58.1%]; reference group), moderate irritability and low depressive/anxious mood (353 [24.7%]), high depressive/anxious mood only (94 [6.6%]), and high irritability and depressive/anxious mood (152 [10.6%]). Children with high irritability and high depressive/anxious mood reported higher rates of suicidality (25 of 152 [16.4%]) compared with the group with the lowest symptom levels (91 of 831 [11.0%]). In logistic regression analyses, the high irritability and depressive/anxious mood profile (odds ratio [OR], 2.22; 95% CI, 1.32-3.74; number needed to be exposed [NNE], 18) was associated with suicidality. To a lesser extent, the moderate irritability and low depressive/anxious mood profile was also associated with suicidality (OR, 1.51; 95% CI, 1.02-2.25; NNE = 48). The high depressive/anxious mood only profile was not associated with later suicidality (OR, 0.96; 95% CI, 0.47-1.95; NNE = -320). The high irritability and depressive/anxious mood profile was associated with a higher suicidal risk compared with the depressive/anxious mood only profile (OR, 2.28; 95% CI, 1.02-5.15). Girls with the high irritability and high depressive/anxious mood profile had higher risk for suicidality (OR, 3.07; 95% CI, 1.54-6.12; NNE = 5). Conclusions and Relevance: Children with high irritability and depressive/anxious mood and, to a lesser extent, with moderate irritability only had a higher suicidal risk during adolescence compared with children with low symptom levels. Early manifestation of chronic irritability during childhood, especially when combined with depressive/anxious mood, may be associated with an elevated risk for adolescent suicidality. The putatively causal role of irritability should be investigated. | |
dc.language.iso | EN | en_US |
dc.subject.en | HEALTHY | |
dc.title.en | Association of Childhood Irritability and Depressive/Anxious Mood Profiles With Adolescent Suicidal Ideation and Attempts | |
dc.title.alternative | JAMA Psychiatry | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1001/jamapsychiatry.2018.0174 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 29590281 | en_US |
bordeaux.journal | JAMA Psychiatry | en_US |
bordeaux.page | 465-473 | en_US |
bordeaux.volume | 75 | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
bordeaux.issue | 5 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.team | HEALTHY_BPH | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.identifier | hal-03194197 | |
hal.version | 1 | |
hal.date.transferred | 2021-04-09T11:39:36Z | |
hal.export | true | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=JAMA%20Psychiatry&rft.date=2018-05-01&rft.volume=75&rft.issue=5&rft.spage=465-473&rft.epage=465-473&rft.eissn=2168-6238%20(Electronic)%202168-622X%20(Linking)&rft.issn=2168-6238%20(Electronic)%202168-622X%20(Linking)&rft.au=ORRI,%20Massimiliano&GALERA,%20Cedric&TURECKI,%20Gustavo&FORTE,%20Alberto&RENAUD,%20Johanne&rft.genre=article |
Fichier(s) constituant ce document
Fichiers | Taille | Format | Vue |
---|---|---|---|
Il n'y a pas de fichiers associés à ce document. |