Mostrar el registro sencillo del ítem

Association of Childhood Irritability and Depressive/Anxious Mood Profiles With Adolescent Suicidal Ideation and Attempts

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorORRI, Massimiliano
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGALERA, Cedric
ORCID: 0000-0003-0549-9608
IDREF: 110034007
dc.contributor.authorTURECKI, Gustavo
dc.contributor.authorFORTE, Alberto
dc.contributor.authorRENAUD, Johanne
dc.contributor.authorBOIVIN, Michel
dc.contributor.authorTREMBLAY, Richard
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOTE, Sylvana
ORCID: 0000-0001-7944-0647
dc.contributor.authorGEOFFROY, Marie Claude
dc.date.accessioned2020-12-14T09:11:27Z
dc.date.available2020-12-14T09:11:27Z
dc.date.issued2018-05-01
dc.identifier.issn2168-6238 (Electronic) 2168-622X (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/21424
dc.description.abstractEnImportance: Suicidal ideation and suicide attempt (suicidality) are common in adolescence and a public health concern. Childhood depression is a key risk factor for later suicidality and often co-occurs with irritability. No study to date has examined the joint association of depressive mood and irritability during childhood with later suicidality. Objective: To investigate the association of childhood irritability and depressive/anxious mood profiles with adolescent suicidality. Design, Setting, and Participants: This population-based cohort study included 1430 participants in the Quebec Longitudinal Study of Child Development. Participants underwent assessment yearly or bi-yearly (5 months to 17 years). Data were collected from March 16, 1998, through July 17, 2015. Exposures: Profiles defined by the joint developmental trajectories of irritability and depressive/anxious mood at 6 to 12 years of age. Main Outcomes and Measures: Self-reported past-year suicidality (ie, serious suicidal ideation or suicide attempt) at 13, 15, and 17 years of age. Irritability and depressive/anxious mood were assessed using teacher report 5 times from 6 to 12 years of age. Results: The study included 1430 participants (676 boys [47.3%] and 754 girls [52.7%]) followed up to 17 years of age. Group-based multitrajectory modeling identified the following profiles: combined no irritability and low depressive/anxious mood with low irritability and low depressive/anxious mood (831 [58.1%]; reference group), moderate irritability and low depressive/anxious mood (353 [24.7%]), high depressive/anxious mood only (94 [6.6%]), and high irritability and depressive/anxious mood (152 [10.6%]). Children with high irritability and high depressive/anxious mood reported higher rates of suicidality (25 of 152 [16.4%]) compared with the group with the lowest symptom levels (91 of 831 [11.0%]). In logistic regression analyses, the high irritability and depressive/anxious mood profile (odds ratio [OR], 2.22; 95% CI, 1.32-3.74; number needed to be exposed [NNE], 18) was associated with suicidality. To a lesser extent, the moderate irritability and low depressive/anxious mood profile was also associated with suicidality (OR, 1.51; 95% CI, 1.02-2.25; NNE = 48). The high depressive/anxious mood only profile was not associated with later suicidality (OR, 0.96; 95% CI, 0.47-1.95; NNE = -320). The high irritability and depressive/anxious mood profile was associated with a higher suicidal risk compared with the depressive/anxious mood only profile (OR, 2.28; 95% CI, 1.02-5.15). Girls with the high irritability and high depressive/anxious mood profile had higher risk for suicidality (OR, 3.07; 95% CI, 1.54-6.12; NNE = 5). Conclusions and Relevance: Children with high irritability and depressive/anxious mood and, to a lesser extent, with moderate irritability only had a higher suicidal risk during adolescence compared with children with low symptom levels. Early manifestation of chronic irritability during childhood, especially when combined with depressive/anxious mood, may be associated with an elevated risk for adolescent suicidality. The putatively causal role of irritability should be investigated.
dc.language.isoENen_US
dc.subject.enHEALTHY
dc.title.enAssociation of Childhood Irritability and Depressive/Anxious Mood Profiles With Adolescent Suicidal Ideation and Attempts
dc.title.alternativeJAMA Psychiatryen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1001/jamapsychiatry.2018.0174en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29590281en_US
bordeaux.journalJAMA Psychiatryen_US
bordeaux.page465-473en_US
bordeaux.volume75en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamHEALTHY_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03194197
hal.version1
hal.date.transferred2021-04-09T11:39:36Z
hal.exporttrue
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=JAMA%20Psychiatry&rft.date=2018-05-01&rft.volume=75&rft.issue=5&rft.spage=465-473&rft.epage=465-473&rft.eissn=2168-6238%20(Electronic)%202168-622X%20(Linking)&rft.issn=2168-6238%20(Electronic)%202168-622X%20(Linking)&rft.au=ORRI,%20Massimiliano&GALERA,%20Cedric&TURECKI,%20Gustavo&FORTE,%20Alberto&RENAUD,%20Johanne&rft.genre=article


Archivos en el ítem

ArchivosTamañoFormatoVer

No hay archivos asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem