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Daily cannabis and reduced risk of steatosis in human immunodeficiency virus and hepatitis C virus-co-infected patients (ANRS CO13-HEPAVIH)

dc.rights.licenseopenen_US
dc.contributor.authorNORDMANN, S.
dc.contributor.authorVILOTITCH, A.
dc.contributor.authorROUX, P.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorESTERLE, Laure
dc.contributor.authorSPIRE, B.
dc.contributor.authorMARCELLIN, F.
dc.contributor.authorSALMON-CERON, D.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDABIS, Francois
dc.contributor.authorCHAS, J.
dc.contributor.authorREY, D.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorWITTKOP, Linda
dc.contributor.authorSOGNI, P.
dc.contributor.authorCARRIERI, P.
dc.date.accessioned2020-12-14T07:46:49Z
dc.date.available2020-12-14T07:46:49Z
dc.date.issued2018-02
dc.identifier.issn1365-2893 (Electronic) 1352-0504 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/21415
dc.description.abstractEnLiver steatosis is common in Human Immunodeficiency Virus (HIV) - Hepatitis C Virus (HCV) co-infected patients. Some recent studies have found that cannabis use is negatively associated with insulin resistance in the general population and in HIV-HCV co-infected patients. Given the causal link between insulin resistance and steatosis, we hypothesized that cannabis use has a positive impact on steatosis. Therefore, we aimed to study whether cannabis use in this population was associated with a reduced risk of steatosis, measured by ultrasound examination. The ANRS CO13-HEPAVIH cohort is a French nationwide multicenter of HIV-HCV co-infected patients. Medical and socio-behavioral data from clinical follow-up visits and annual self-administered questionnaires were prospectively collected. A cross-sectional analysis was conducted using data from the first visit where both ultrasound examination data for steatosis (positive or negative diagnosis) and data on cannabis use were available. A logistic regression model was used to evaluate the association between cannabis use and steatosis. Among study sample patients (n=838), 40.1% had steatosis. Fourteen percent reported daily cannabis use, 11.7% regular use, and 74.7% no use or occasional use ("never or sometimes"). Daily cannabis use was independently associated with a reduced prevalence of steatosis (adjusted odds ratio [95%]=0.64 [0.42;0.99]; p=0.046), after adjusting for body mass index, hazardous alcohol consumption and current or lifetime use of lamivudine/zidovudine. Daily cannabis use may be a protective factor against steatosis in HIV-HCV co-infected patients. These findings confirm the need for a clinical evaluation of cannabis-based pharmacotherapies in this population. Eudract.ema.europa.eu number, DGS050367. This article is protected by copyright. All rights reserved.
dc.language.isoENen_US
dc.subject.enCREDIM
dc.subject.enMORPH3Eus
dc.subject.enANRS CO13 - HEPAVIH
dc.title.enDaily cannabis and reduced risk of steatosis in human immunodeficiency virus and hepatitis C virus-co-infected patients (ANRS CO13-HEPAVIH)
dc.title.alternativeJ Viral Hepaten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/jvh.12797en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed28984055en_US
bordeaux.journalJournal of viral hepatitisen_US
bordeaux.page171-179en_US
bordeaux.volume2en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamCREDIMen_US
bordeaux.teamMORPH3Eusen_US
bordeaux.teamANRS CO13 - HEPAVIHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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