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Prognostic Values of Inflammatory and Redox Status Biomarkers on the Risk of Major Lower-Extremity Artery Disease in Individuals With Type 2 Diabetes

dc.rights.licenseopenen_US
dc.contributor.authorNATIVEL, M.
dc.contributor.authorSCHNEIDER, F.
dc.contributor.authorSAULNIER, P. J.
dc.contributor.authorGAND, E.
dc.contributor.authorRAGOT, S.
dc.contributor.authorMEILHAC, O.
dc.contributor.authorRONDEAU, P.
dc.contributor.authorBURILLO, E.
dc.contributor.authorCOURNOT, M.
dc.contributor.authorPOTIER, L.
dc.contributor.authorVELHO, G.
dc.contributor.authorMARRE, M.
dc.contributor.authorROUSSEL, R.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRIGALLEAU, Vincent
IDREF: 069788146
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMOHAMMEDI, Kamel
dc.contributor.authorHADJADJ, S.
dc.date.accessioned2020-12-08T15:43:36Z
dc.date.available2020-12-08T15:43:36Z
dc.date.issued2018-10
dc.identifier.issn1935-5548 (Electronic) 0149-5992 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/21374
dc.description.abstractEnOBJECTIVE: Inflammation and oxidative stress play an important role in the pathogenesis of lower-extremity artery disease (LEAD). We assessed the prognostic values of inflammatory and redox status biomarkers on the risk of LEAD in individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS: Plasma concentrations of tumor necrosis factor-alpha receptor 1 (TNFR1), angiopoietin-like 2, ischemia-modified albumin (IMA), fluorescent advanced glycation end products, protein carbonyls, and total reductive capacity of plasma were measured at baseline in the SURDIAGENE (Survie, Diabete de type 2 et Genetique) cohort. Major LEAD was defined as the occurrence during follow-up of peripheral revascularization or lower-limb amputation. RESULTS: Among 1,412 participants at baseline (men 58.2%, mean [SD] age 64.7 [10.6] years), 112 (7.9%) developed major LEAD during 5.6 years of follow-up. High plasma concentrations of TNFR1 (HR [95% CI] for second vs. first tertile 1.12 [0.62-2.03; P = 0.71], third vs. first tertile 2.16 [1.19-3.92; P = 0.01]) and IMA (2.42 [1.38-4.23; P = 0.002], 2.04 [1.17-3.57; P = 0.01]) were independently associated with an increased risk of major LEAD. Plasma concentrations of TNFR1 but not IMA yielded incremental information, over traditional risk factors, for the risk of major LEAD as follows: C-statistic change (0.036 [95% CI 0.013-0.059]; P = 0.002), integrated discrimination improvement (0.012 [0.005-0.022]; P < 0.001), continuous net reclassification improvement (NRI) (0.583 [0.294-0.847]; P < 0.001), and categorical NRI (0.171 [0.027-0.317]; P = 0.02). CONCLUSIONS: Independent associations exist between high plasma TNFR1 or IMA concentrations and increased 5.6-year risk of major LEAD in people with type 2 diabetes. TNFR1 allows incremental prognostic information, suggesting its use as a biomarker for LEAD.
dc.language.isoENen_US
dc.subject.enLEHA
dc.title.enPrognostic Values of Inflammatory and Redox Status Biomarkers on the Risk of Major Lower-Extremity Artery Disease in Individuals With Type 2 Diabetes
dc.title.alternativeDiabetes Careen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.2337/dc18-0695en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30072406en_US
bordeaux.journalDiabetes Careen_US
bordeaux.page2162-2169en_US
bordeaux.volume41en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue10en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamLEHA_BPH
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03193178
hal.version1
hal.date.transferred2021-04-08T13:48:11Z
hal.exporttrue
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