Human papillomavirus vaccine and demyelinating diseases-A systematic review and meta-analysis
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | MOUCHET, Julie | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SALVO, Francesco | |
| dc.contributor.author | RASCHI, E. | |
| dc.contributor.author | POLUZZI, E. | |
| dc.contributor.author | ANTONAZZO, I. C. | |
| dc.contributor.author | DE PONTI, F. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BEGAUD, Bernard | |
| dc.date.accessioned | 2020-12-08T14:14:57Z | |
| dc.date.available | 2020-12-08T14:14:57Z | |
| dc.date.issued | 2018-06 | |
| dc.identifier.issn | 1096-1186 (Electronic) 1043-6618 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/21365 | |
| dc.description.abstractEn | BACKGROUND: Approved in 2006, human papillomavirus (HPV) vaccines were initially targeted for girls aged 9-14 years. Although the safety of these vaccines has been monitored through post-licensure surveillance programmes, cases of neurological events have been reported worldwide. PURPOSE: The present study aimed to assess the risk of developing demyelination after HPV immunization by meta-analysing risk estimates from pharmacoepidemiologic studies. DATA SOURCES: A systematic review was conducted in Medline, Embase, ISI Web of Science and the Cochrane Library from inception to 10 May 2017, without language restriction. STUDY SELECTION: Only observational studies including a control group were retained. Study selection was performed by two independent reviewers with disagreements solved through discussion. DATA EXTRACTION: This meta-analysis was performed using a generic inverse variance random-effect model. Outcomes of interest included a broad category of central demyelination, multiple sclerosis (MS), optic neuritis (ON), and Guillain-Barre syndrome (GBS), each being considered independently. Heterogeneity was investigated; sensitivity and subgroup analyses were performed when necessary. In parallel, post-licensure safety studies were considered for a qualitative review. This study followed the PRISMA statement and the MOOSE reporting guideline. DATA SYNTHESIS: Of the 2863 references identified, 11 articles were selected for meta-analysis. No significant association emerged between HPV vaccination and central demyelination, the pooled odds ratio being 0.96 [95%CI 0.77-1.20], with a moderate but non-significant heterogeneity (I(2)=29%). Similar results were found for MS and ON. Sensitivity analyses did not alter our conclusions. Findings from qualitative review of 14 safety studies concluded in an absence of a relevant signal. LIMITATIONS: Owing to limited data on GBS, no meta-analysis was performed for this outcome. CONCLUSION: This study strongly supports the absence of association between HPV vaccines and central demyelination. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | PharmacoEpi-Drugs | |
| dc.title.en | Human papillomavirus vaccine and demyelinating diseases-A systematic review and meta-analysis | |
| dc.title.alternative | Pharmacol Res | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.phrs.2018.04.007 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 29665426 | en_US |
| bordeaux.journal | Pharmacological Research | en_US |
| bordeaux.page | 108-118 | en_US |
| bordeaux.volume | 132 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | PharmacoEpi-Drugs | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03194177 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-04-09T11:30:50Z | |
| hal.export | true | |
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