Anxiety and 10-Year Risk of Incident Dementia-An Association Shaped by Depressive Symptoms: Results of the Prospective Three-City Study
| dc.rights.license | open | en_US |
| dc.contributor.author | MORTAMAIS, M. | |
| dc.contributor.author | ABDENNOUR, M. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BERGUA, Valerie
ORCID: 0000-0002-2232-1812 IDREF: 09428895X | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | TZOURIO, Christophe
IDREF: 69829209 | |
| dc.contributor.author | BERR, C. | |
| dc.contributor.author | GABELLE, A. | |
| dc.contributor.author | AKBARALY, T. N. | |
| dc.date.accessioned | 2020-12-08T13:46:09Z | |
| dc.date.available | 2020-12-08T13:46:09Z | |
| dc.date.issued | 2018-04-17 | |
| dc.identifier.issn | 1662-4548 (Print) 1662-453X (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/21361 | |
| dc.description.abstractEn | Background: Anxiety is common in patients with cognitive impairment and dementia. However, whether anxiety is a risk factor for dementia is still not known. We aimed to examine the association between trait anxiety at baseline and the 10-year risk of incident dementia to determine to which extent depressive symptoms influence this relationship in the general population. Methods: Data came from 5,234 community-dwelling participants from the Three-City prospective cohort study, aged 65 years at baseline and followed over 10 years. At baseline, anxiety trait was assessed using the Spielberger State-Trait Anxiety Inventory (STAI), and depressive symptoms using Center for Epidemiologic Studies-Depression Scale (CESD). Use of anxiolytic drugs was also considered. Diagnoses of dementia were made at baseline and every 2 years. To examine the relationship between anxiety exposures and risk of incident dementia, Cox proportional hazard regression models were performed. Results: Taking anxiolytic drugs or having high trait anxiety (STAI score >/= 44) increased the risk of dementia assessed over 10 years of follow-up [Hazard Ratio (HR) = 1.39, 95%CI: 1.08-1.80, p = 0.01 and HR = 1.26, 95%CI: 1.01-1.57, p = 0.04, respectively], independently of a large panel of socio-demographic variables, health behaviors, cardio-metabolic disorders, and additional age-related disorders such as cardiovascular diseases, activity limitations, and cognitive deficit. However, the associations were substantially attenuated after further adjustment for depressive symptoms. Conclusion: Our findings suggest that depressive symptoms shape the association between anxiety trait and dementia. Further research is needed to replicate our findings and extrapolate our results to anxiety disorders. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | SEPIA | |
| dc.subject.en | VINTAGE | |
| dc.title.en | Anxiety and 10-Year Risk of Incident Dementia-An Association Shaped by Depressive Symptoms: Results of the Prospective Three-City Study | |
| dc.title.alternative | Front Neurosci | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3389/fnins.2018.00248 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 29719498 | en_US |
| bordeaux.journal | Frontiers in neuroscience | en_US |
| bordeaux.page | 248 | en_US |
| bordeaux.volume | 12 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | SEPIA | en_US |
| bordeaux.team | VINTAGE | en_US |
| bordeaux.team | HEALTHY_BPH | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20neuroscience&rft.date=2018-04-17&rft.volume=12&rft.spage=248&rft.epage=248&rft.eissn=1662-4548%20(Print)%201662-453X%20(Linking)&rft.issn=1662-4548%20(Print)%201662-453X%20(Linking)&rft.au=MORTAMAIS,%20M.&ABDENNOUR,%20M.&BERGUA,%20Valerie&TZOURIO,%20Christophe&BERR,%20C.&rft.genre=article |
