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Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

dc.rights.licenseopenen_US
dc.contributor.authorMAUSCHITZ, M. M.
dc.contributor.authorBONNEMAIJER, P. W. M.
dc.contributor.authorDIERS, K.
dc.contributor.authorRAUSCHER, F. G.
dc.contributor.authorELZE, T.
dc.contributor.authorENGEL, C.
dc.contributor.authorLOEFFLER, M.
dc.contributor.authorCOLIJN, J. M.
dc.contributor.authorIKRAM, M. A.
dc.contributor.authorVINGERLING, J. R.
dc.contributor.authorWILLIAMS, K. M.
dc.contributor.authorHAMMOND, C. J.
dc.contributor.authorCREUZOT-GARCHER, C.
dc.contributor.authorBRON, A. M.
dc.contributor.authorSILVA, R.
dc.contributor.authorNUNES, S.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELCOURT, Cécile
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOUGNARD-GREGOIRE, Audrey
dc.contributor.authorHOLZ, F. G.
dc.contributor.authorKLAVER, C. C. W.
dc.contributor.authorBRETELER, M. M. B.
dc.contributor.authorFINGER, R. P.
dc.date.accessioned2020-12-07T12:55:28Z
dc.date.available2020-12-07T12:55:28Z
dc.date.issued2018-10
dc.identifier.issn1549-4713 (Electronic) 0161-6420 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/21326
dc.description.abstractEnPURPOSE: To investigate systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness (pRNFLT) in the European population. DESIGN: Cross-sectional meta-analysis. PARTICIPANTS: A total of 16 084 European adults from 8 cohort studies (mean age range, 56.9+/-12.3-82.1+/-4.2 years) of the European Eye Epidemiology (E3) consortium. METHODS: We examined associations with pRNFLT measured by spectral-domain OCT in each study using multivariable linear regression and pooled results using random effects meta-analysis. MAIN OUTCOME MEASURES: Determinants of pRNFLT. RESULTS: Mean pRNFLT ranged from 86.8+/-21.4 mum in the Rotterdam Study I to 104.7+/-12.5 mum in the Rotterdam Study III. We found the following factors to be associated with reduced pRNFLT: Older age (beta = -0.38 mum/year; 95% confidence interval [CI], -0.57 to -0.18), higher intraocular pressure (IOP) (beta = -0.36 mum/mmHg; 95% CI, -0.56 to -0.15), visual impairment (beta = -5.50 mum; 95% CI, -9.37 to -1.64), and history of systemic hypertension (beta = -0.54 mum; 95% CI, -1.01 to -0.07) and stroke (beta = -1.94 mum; 95% CI, -3.17 to -0.72). A suggestive, albeit nonsignificant, association was observed for dementia (beta = -3.11 mum; 95% CI, -6.22 to 0.01). Higher pRNFLT was associated with more hyperopic spherical equivalent (beta = 1.39 mum/diopter; 95% CI, 1.19-1.59) and smoking (beta = 1.53 mum; 95% CI, 1.00-2.06 for current smokers compared with never-smokers). CONCLUSIONS: In addition to previously described determinants such as age and refraction, we found that systemic vascular and neurovascular diseases were associated with reduced pRNFLT. These may be of clinical relevance, especially in glaucoma monitoring of patients with newly occurring vascular comorbidities.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enLEHA
dc.title.enSystemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population
dc.title.alternativeOphthalmologyen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.ophtha.2018.03.026en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29716786en_US
bordeaux.journalOphthalmologyen_US
bordeaux.page1526-1536en_US
bordeaux.volume125en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue10en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamLEHA_BPH
bordeaux.teamHEALTHY_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Ophthalmology&rft.date=2018-10&rft.volume=125&rft.issue=10&rft.spage=1526-1536&rft.epage=1526-1536&rft.eissn=1549-4713%20(Electronic)%200161-6420%20(Linking)&rft.issn=1549-4713%20(Electronic)%200161-6420%20(Linking)&rft.au=MAUSCHITZ,%20M.%20M.&BONNEMAIJER,%20P.%20W.%20M.&DIERS,%20K.&RAUSCHER,%20F.%20G.&ELZE,%20T.&rft.genre=article


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