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Prevalence of Hypertension in Children with Early-Stage ADPKD

dc.rights.licenseopenen_US
dc.contributor.authorMASSELLA, L.
dc.contributor.authorMEKAHLI, D.
dc.contributor.authorPARIPOVIC, D.
dc.contributor.authorPRIKHODINA, L.
dc.contributor.authorGODEFROID, N.
dc.contributor.authorNIEMIRSKA, A.
dc.contributor.authorAGBAS, A.
dc.contributor.authorKALICKA, K.
dc.contributor.authorJANKAUSKIENE, A.
dc.contributor.authorMIZERSKA-WASIAK, M.
dc.contributor.authorAFONSO, A. C.
dc.contributor.authorSALOMON, R.
dc.contributor.authorDESCHENES, G.
dc.contributor.authorARICETA, G.
dc.contributor.authorOZCAKAR, Z. B.
dc.contributor.authorTEIXEIRA, A.
dc.contributor.authorDUZOVA, A.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHARAMBAT, Jerome
dc.contributor.authorSEEMAN, T.
dc.contributor.authorHRCKOVA, G.
dc.contributor.authorLUNGU, A. C.
dc.contributor.authorPAPIZH, S.
dc.contributor.authorPECO-ANTIC, A.
dc.contributor.authorDE RECHTER, S.
dc.contributor.authorGIORDANO, U.
dc.contributor.authorKIRCHNER, M.
dc.contributor.authorLUTZ, T.
dc.contributor.authorSCHAEFER, F.
dc.contributor.authorDEVUYST, O.
dc.contributor.authorWUHL, E.
dc.contributor.authorEMMA, F.
dc.date.accessioned2020-12-07T10:43:45Z
dc.date.available2020-12-07T10:43:45Z
dc.date.issued2018-06-07
dc.identifier.issn1555-905X (Electronic) 1555-9041 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/21321
dc.description.abstractEnBACKGROUND AND OBJECTIVES: Autosomal dominant polycystic kidney disease is the most common inheritable kidney disease, frequently thought to become symptomatic in adulthood. However, patients with autosomal dominant polycystic kidney disease may develop signs or symptoms during childhood, in particular hypertension. Although ambulatory BP monitoring is the preferred method to diagnose hypertension in pediatrics, data in children with autosomal dominant polycystic kidney disease are limited. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Our retrospective multicenter study was conducted to collect ambulatory BP monitoring recordings from patients with autosomal dominant polycystic kidney disease age <18 years old. Basic anthropometric parameters as well as data on kidney function, BP treatment, and kidney ultrasound were also collected. RESULTS: Data from 310 children with autosomal dominant polycystic kidney disease with a mean age of 11.5+/-4.1 years old were collected at 22 European centers. At the time when ambulatory BP monitoring was performed, 95% of children had normal kidney function. Reference data for ambulatory BP monitoring were available for 292 patients. The prevalence rates of children with hypertension and/or those who were treated with antihypertensive drugs were 31%, 42%, and 35% during daytime, nighttime, or the entire 24-hour cycle, respectively. In addition, 52% of participants lacked a physiologic nocturnal BP dipping, and 18% had isolated nocturnal hypertension. Logistic regression analysis showed a significant association between a categorical cyst score that was calculated on the basis of the number of cysts >1 cm per kidney and daytime hypertension (odds ratio, 1.70; 95% confidence interval, 1.21 to 2.4; P=0.002), nighttime hypertension (odds ratio, 1.31; 95% confidence interval, 1.05 to 1.63; P=0.02), or 24-hour hypertension (odds ratio, 1.39; 95% confidence interval, 1.08 to 1.81; P=0.01). Kidney length, expressed as SD score, was also significantly associated with nighttime hypertension (odds ratio, 1.23; 95% confidence interval, 1.06 to 1.42; P=0.10). CONCLUSIONS: These data indicate high prevalence of hypertension in children with autosomal dominant polycystic kidney disease starting at young ages.
dc.language.isoENen_US
dc.subject.enLEHA
dc.title.enPrevalence of Hypertension in Children with Early-Stage ADPKD
dc.title.alternativeClin J Am Soc Nephrolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.2215/cjn.11401017en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29674338en_US
bordeaux.journalClinical Journal of the American Society of Nephrologyen_US
bordeaux.page874-883en_US
bordeaux.volume13en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue6en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03193058
hal.version1
hal.date.transferred2021-04-08T13:22:39Z
hal.exporttrue
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