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HIV is associated with airway obstruction: a matched controlled study

dc.rights.licenseopenen_US
dc.contributor.authorMAKINSON, A.
dc.contributor.authorHAYOT, M.
dc.contributor.authorEYMARD-DUVERNAY, S.
dc.contributor.authorRIBET, C.
dc.contributor.authorRAFFI, F.
dc.contributor.authorPIALOUX, G.
dc.contributor.authorZUCMAN, D.
dc.contributor.authorPOIZOT-MARTIN, I.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBONNET, Fabrice
dc.contributor.authorABGRALL, S.
dc.contributor.authorTATTEVIN, P.
dc.contributor.authorCHERET, A.
dc.contributor.authorFERRY, T.
dc.contributor.authorMAUBOUSSIN, J. M.
dc.contributor.authorMARCHAND, L.
dc.contributor.authorROUZAUD, C.
dc.contributor.authorREYNES, J.
dc.contributor.authorZINS, M.
dc.contributor.authorLE MOING, V.
dc.date.accessioned2020-11-30T15:28:31Z
dc.date.available2020-11-30T15:28:31Z
dc.date.issued2018-01-14
dc.identifier.issn1473-5571 (Electronic) 0269-9370 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/21273
dc.description.abstractEnOBJECTIVE: To explore whether airway obstruction is associated with HIV in a cohort of HIV-infected and uninfected smokers. METHODS: People living with HIV (PLWHIV) participated in the ANRS EP48 HIV CHEST study, an early lung cancer diagnosis study with low-dose chest tomography. HIV-uninfected study participants were from the CONSTANCES cohort. Inclusion criteria were an age greater than 40 years, a smoking history of at least 20 pack-years, and for PLWHIV, a CD4 T-lymphocyte nadir less than 350/mul and last CD4 cell count more than 100 cells/mul. Two randomly selected HIV-uninfected study participants were matched by age and sex with one PLWHIV. Prebronchodilatator forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) ratio was the primary outcome, and association of FEV1/FVC ratio less than 0.70 and FEV1 less than 80% of the theoretical value, as a proxy of chronic obstructive pulmonary disease, the secondary outcome. RESULTS: In total, 351 PLWHIV and 702 HIV-uninfected study participants were included. Median age was 50 years, and 17% of study participants were women. Plasma HIV RNA was less than 50 copies/ml in 89% of PLWHIV, with a median CD4 cell count of 573 cells/mul. HIV (beta -2.19), age (per 10 years increase; beta -2.81), tobacco use (per 5 pack-years increase; beta -0.34), and hepatitis C virus serology (beta-2.50) were negatively associated with FEV1/FVC. HIV [odds ratio (OR: 1.72)], age (per 10 years increase; OR 1.77), and tobacco use (per 5 pack-years increase; OR 1.11) were significantly associated with the secondary outcome. CONCLUSION: Our study found a significant association of airway obstruction with HIV status in smokers aged more than 40 years with previous immunodeficiency.
dc.language.isoENen_US
dc.subject.enMORPH3Eus
dc.title.enHIV is associated with airway obstruction: a matched controlled study
dc.title.alternativeAIDSen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/qad.0000000000001691en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29135582en_US
bordeaux.journalAIDS (London, England)en_US
bordeaux.page227-232en_US
bordeaux.volume32en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamMORPH3Eusen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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