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Occupational exposures and 20-year incidence of COPD: the European Community Respiratory Health Survey

dc.rights.licenseopenen_US
dc.contributor.authorLYTRAS, T.
dc.contributor.authorKOGEVINAS, M.
dc.contributor.authorKROMHOUT, H.
dc.contributor.authorCARSIN, A. E.
dc.contributor.authorANTO, J. M.
dc.contributor.authorBENTOUHAMI, H.
dc.contributor.authorWEYLER, J.
dc.contributor.authorHEINRICH, J.
dc.contributor.authorNOWAK, D.
dc.contributor.authorURRUTIA, I.
dc.contributor.authorMARTINEZ-MORATALLA, J.
dc.contributor.authorGULLON, J. A.
dc.contributor.authorPEREIRA-VEGA, A.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRAHERISON-SEMJEN, Chantal
dc.contributor.authorPIN, I.
dc.contributor.authorDEMOLY, P.
dc.contributor.authorLEYNAERT, B.
dc.contributor.authorVILLANI, S.
dc.contributor.authorGISLASON, T.
dc.contributor.authorSVANES, C.
dc.contributor.authorHOLM, M.
dc.contributor.authorFORSBERG, B.
dc.contributor.authorNORBACK, D.
dc.contributor.authorMEHTA, A. J.
dc.contributor.authorPROBST-HENSCH, N.
dc.contributor.authorBENKE, G.
dc.contributor.authorJOGI, R.
dc.contributor.authorTOREN, K.
dc.contributor.authorSIGSGAARD, T.
dc.contributor.authorSCHLUNSSEN, V.
dc.contributor.authorOLIVIERI, M.
dc.contributor.authorBLANC, P. D.
dc.contributor.authorVERMEULEN, R.
dc.contributor.authorGARCIA-AYMERICH, J.
dc.contributor.authorJARVIS, D.
dc.contributor.authorZOCK, J. P.
dc.date.accessioned2020-11-30T14:48:29Z
dc.date.available2020-11-30T14:48:29Z
dc.date.issued2018-11
dc.identifier.issn1468-3296 (Electronic) 0040-6376 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/21271
dc.description.abstractEnBACKGROUND: Occupational exposures have been associated with an increased risk of COPD. However, few studies have related objectively assessed occupational exposures to prospectively assessed incidence of COPD, using postbronchodilator lung function tests. Our objective was to examine the effect of occupational exposures on COPD incidence in the European Community Respiratory Health Survey. METHODS: General population samples aged 20-44 were randomly selected in 1991-1993 and followed up 20 years later (2010-2012). Spirometry was performed at baseline and at follow-up, with incident COPD defined using a lower limit of normal criterion for postbronchodilator FEV1/FVC. Only participants without COPD and without current asthma at baseline were included. Coded job histories during follow-up were linked to a Job-Exposure Matrix, generating occupational exposure estimates to 12 categories of agents. Their association with COPD incidence was examined in log-binomial models fitted in a Bayesian framework. FINDINGS: 3343 participants fulfilled the inclusion criteria; 89 of them had COPD at follow-up (1.4 cases/1000 person-years). Participants exposed to biological dust had a higher incidence of COPD compared with those unexposed (relative risk (RR) 1.6, 95% CI 1.1 to 2.3), as did those exposed to gases and fumes (RR 1.5, 95% CI 1.0 to 2.2) and pesticides (RR 2.2, 95% CI 1.1 to 3.8). The combined population attributable fraction for these exposures was 21.0%. INTERPRETATION: These results substantially strengthen the evidence base for occupational exposures as an important risk factor for COPD.
dc.language.isoENen_US
dc.subject.enEPICENE
dc.title.enOccupational exposures and 20-year incidence of COPD: the European Community Respiratory Health Survey
dc.title.alternativeThoraxen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1136/thoraxjnl-2017-211158en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29574416en_US
bordeaux.journalThoraxen_US
bordeaux.page1008-1015en_US
bordeaux.volume73en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue11en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamEPICENE_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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