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Present and future of disease-modifying therapies in multiple system atrophy

dc.rights.licenseopenen_US
dc.contributor.authorLOPEZ-CUINA, M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIER FOUBERT, Alexandra
dc.contributor.authorTISON, F.
dc.contributor.authorMEISSNER, W. G.
dc.date.accessioned2020-11-30T13:18:21Z
dc.date.available2020-11-30T13:18:21Z
dc.date.issued2018-05
dc.identifier.issn1566-0702en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/21264
dc.description.abstractEnThrough the last decade seven clinical trials on Multiple System Atrophy have been published, virtually all of them reported negative results. Patients and family remain hopeful while facing this devastating disease, but as doctors we still cannot offer them disease-modifying therapies. The field has seen many advances regarding pathophysiology, translational research, diagnostic accuracy, natural history and imaging, but successful treatment remains elusive. This review provides an overview of the available tools for designing clinical trials, critically analyzes the past studies and describes the knowledge obtained from them, and finally gives some orientation for future trials that could meet the current needs of patients and clinicians, overcoming the hurdles met by previous studies.
dc.language.isoENen_US
dc.subject.enSEPIA
dc.title.enPresent and future of disease-modifying therapies in multiple system atrophy
dc.title.alternativeAuton Neuroscien_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.autneu.2017.12.008en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29311010en_US
bordeaux.journalAutonomic neuroscienceen_US
bordeaux.page31-38en_US
bordeaux.volume211en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSEPIAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03031344
hal.version1
hal.date.transferred2020-11-30T13:18:24Z
hal.exporttrue
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