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Pattern of polyphenol intake and the long-term risk of dementia in older persons

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEFEVRE ARBOGAST, Sophie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGAUDOUT, David
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBENSALEM, Julien
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLETENNEUR, Luc
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHEJBLUM, Boris
ORCID: 0000-0003-0646-452X
IDREF: 189970316
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFEART-COURET, Catherine
ORCID: 0000-0002-7959-1610
IDREF: 08195848X
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELCOURT, Cecile
ORCID: 0000-0002-2099-0481
IDREF: 035105291
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIERI, Cecilia
dc.date.accessioned2020-11-30T10:17:11Z
dc.date.available2020-11-30T10:17:11Z
dc.date.issued2018-05-29
dc.identifier.issn1526-632X (Electronic) 0028-3878 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/21254
dc.description.abstractEnOBJECTIVE: To investigate the optimal combination of dietary polyphenols associated with the long-term risk of dementia in a large prospective French cohort of older persons, the Three-City (3C) Study. METHODS: We included 1,329 older adults without dementia from the 3C study with assessment of intake of 26 polyphenol subclasses who were followed up for 12 years for dementia. Using partial least squares for Cox models, we identified a pattern of polyphenol intake associated with dementia risk. RESULTS: The pattern combined several flavonoids (dihydroflavonols, anthocyanins, isoflavonoids, flavanones), stilbenes (including resveratrol), lignans, and other subclasses (hydroxybenzaldehydes, naphthoquinones, furanocoumarins). Compared with participants in the lower quintile of pattern score, those in the higher quintile had a 50% lower risk of dementia (95% confidence interval 20%-68%, p for trend <0.01) in multivariate models. CONCLUSIONS: In this French cohort, a polyphenol pattern provided by a diet containing specific plant products (nuts, citrus, berries, leafy vegetables, soy, cereals, olive oil) accompanied by red wine and tea was associated with lower dementia risk.
dc.language.isoENen_US
dc.subject.enLEHA
dc.subject.enSISTM
dc.subject.enSEPIA
dc.title.enPattern of polyphenol intake and the long-term risk of dementia in older persons
dc.title.alternativeNeurologyen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1212/wnl.0000000000005607en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29703769en_US
bordeaux.journalNeurologyen_US
bordeaux.pagee1979-e1988en_US
bordeaux.volume90en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue22en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSISTM_BPHen_US
bordeaux.teamLEHA_BPH
bordeaux.teamSEPIAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Neurology&amp;rft.date=2018-05-29&amp;rft.volume=90&amp;rft.issue=22&amp;rft.spage=e1979-e1988&amp;rft.epage=e1979-e1988&amp;rft.eissn=1526-632X%20(Electronic)%200028-3878%20(Linking)&amp;rft.issn=1526-632X%20(Electronic)%200028-3878%20(Linking)&amp;rft.au=LEFEVRE%20ARBOGAST,%20Sophie&amp;GAUDOUT,%20David&amp;BENSALEM,%20Julien&amp;LETENNEUR,%20Luc&amp;DARTIGUES,%20Jean-Francois&amp;rft.genre=article


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