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CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse.

dc.rights.licenseopen
dc.contributor.authorUEHARA, Masayuki
dc.contributor.authorYASHIRO, Kenta
dc.contributor.authorMAMIYA, Satoru
dc.contributor.authorNISHINO, Jinsuke
hal.structure.identifierLaboratoire de Chimie des polymères organiques [LCPO]
dc.contributor.authorCHAMBON, Pierre
dc.contributor.authorDOLLE, Pascal
hal.structure.identifierBiomécanique et génie biomédical [BIM]
dc.contributor.authorSAKAI, Yasuo
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2007
dc.identifier.issn0012-1606
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20855
dc.description.abstractEnThe appropriate regulation of retinoic acid signaling is indispensable for patterning of the vertebrate central nervous system along the anteroposterior (A-P) axis. Although both CYP26A1 and CYP26C1, retinoic acid-degrading enzymes that are expressed at the anterior end of the gastrulating mouse embryo, have been thought to play an important role in central nervous system patterning, the detailed mechanism of their contribution has remained largely unknown. We have now analyzed CYP26A1 and CYP26C1 function by generating knockout mice. Loss of CYP26C1 did not appear to affect embryonic development, suggesting that CYP26A1 and CYP26C1 are functionally redundant. In contrast, mice lacking both CYP26A1 and CYP26C1 were found to manifest a pronounced anterior truncation of the brain associated with A-P patterning defects that reflect expansion of posterior identity at the expense of anterior identity. Furthermore, Cyp26a1-/-Cyp26c1-/- mice fail to produce migratory cranial neural crest cells in the forebrain and midbrain. These observations, together with a reevaluation of Cyp26a1 mutant mice, suggest that the activity of CYP26A1 and CYP26C1 is required for correct A-P patterning and production of migratory cranial neural crest cells in the developing mammalian brain.
dc.language.isoen
dc.publisherElsevier
dc.subject.meshAnimals
dc.subject.meshBody Patterning
dc.subject.meshSignal Transduction
dc.subject.meshSkull
dc.subject.meshTretinoin
dc.subject.meshBrain
dc.subject.meshCell Movement
dc.subject.meshCytochrome P-450 Enzyme System
dc.subject.meshMesencephalon
dc.subject.meshMice
dc.subject.meshMice, Knockout
dc.subject.meshNeural Crest
dc.subject.meshProsencephalon
dc.title.enCYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse.
dc.typeArticle de revue
dc.identifier.doi10.1016/j.ydbio.2006.09.045
dc.subject.halSciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biologie moléculaire
bordeaux.journalDevelopmental Biology
bordeaux.page399-411
bordeaux.volume302
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue2
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-00166242
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00166242v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Developmental%20Biology&rft.date=2007&rft.volume=302&rft.issue=2&rft.spage=399-411&rft.epage=399-411&rft.eissn=0012-1606&rft.issn=0012-1606&rft.au=UEHARA,%20Masayuki&YASHIRO,%20Kenta&MAMIYA,%20Satoru&NISHINO,%20Jinsuke&CHAMBON,%20Pierre&rft.genre=article


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