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A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency.

dc.rights.licenseopen
dc.contributor.authorWALKLEY, Carl R
dc.contributor.authorOLSEN, Gemma Haines
dc.contributor.authorDWORKIN, Sebastian
dc.contributor.authorFABB, Stewart A
dc.contributor.authorSWANN, Jeremy
dc.contributor.authorMCARTHUR, Grant A
dc.contributor.authorWESTMORELAND, Susan V
hal.structure.identifierLaboratoire de Chimie des polymères organiques [LCPO]
dc.contributor.authorCHAMBON, Pierre
dc.contributor.authorSCADDEN, David T
dc.contributor.authorPURTON, Louise E
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2007
dc.identifier.issn0092-8674
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20854
dc.description.abstractEnMyeloproliferative syndromes (MPS) are a heterogeneous subclass of nonlymphoid hematopoietic neoplasms which are considered to be intrinsic to hematopoietic cells. The causes of MPS are largely unknown. Here, we demonstrate that mice deficient for retinoic acid receptor gamma (RARgamma), develop MPS induced solely by the RARgamma-deficient microenvironment. RARgamma(-/-) mice had significantly increased granulocyte/macrophage progenitors and granulocytes in bone marrow (BM), peripheral blood, and spleen. The MPS phenotype continued for the lifespan of the mice and was more pronounced in older mice. Unexpectedly, transplant studies revealed this disease was not intrinsic to the hematopoietic cells. BM from wild-type mice transplanted into mice with an RARgamma(-/-) microenvironment rapidly developed the MPS, which was partially caused by significantly elevated TNFalpha in RARgamma(-/-) mice. These data show that loss of RARgamma results in a nonhematopoietic cell-intrinsic MPS, revealing the capability of the microenvironment to be the sole cause of hematopoietic disorders.
dc.language.isoen
dc.publisherElsevier
dc.title.enA microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency.
dc.typeArticle de revue
dc.identifier.doi10.1016/j.cell.2007.05.014
dc.subject.halSciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biologie moléculaire
bordeaux.journalCell
bordeaux.page1097-110
bordeaux.volume129
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue6
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-00166246
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00166246v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cell&rft.date=2007&rft.volume=129&rft.issue=6&rft.spage=1097-110&rft.epage=1097-110&rft.eissn=0092-8674&rft.issn=0092-8674&rft.au=WALKLEY,%20Carl%20R&OLSEN,%20Gemma%20Haines&DWORKIN,%20Sebastian&FABB,%20Stewart%20A&SWANN,%20Jeremy&rft.genre=article


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