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Biodegradable polycarbonate-b-polypeptide and polyester-b-polypeptide block copolymers: Synthesis and nanoparticle formation towards biomaterials

dc.rights.licenseopen
hal.structure.identifierLaboratoire de Chimie des polymères organiques [LCPO]
dc.contributor.authorLE HELLAYE, Maude
hal.structure.identifierLaboratoire de Chimie des polymères organiques [LCPO]
dc.contributor.authorFORTIN, Nicolas
hal.structure.identifierLaboratoire de Chimie des polymères organiques [LCPO]
dc.contributor.authorGUILLOTEAU, Julien
hal.structure.identifierLaboratoire de Chimie des polymères organiques [LCPO]
hal.structure.identifierTeam 1 LCPO : Polymerization Catalyses & Engineering
dc.contributor.authorSOUM, Alain
hal.structure.identifierLaboratoire de Chimie des polymères organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
hal.structure.identifierInstitut des Sciences Chimiques de Rennes [ISCR]
dc.contributor.authorGUILLAUME, Sophie M.
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2008
dc.identifier.issn1525-7797
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20793
dc.description.abstractEnThe amino poly(trimethylene carbonate)-NHt-Boc (PTMC-NHt-Boc) and poly(E-caprolactone)-NHt-Boc (PCL-NHt-Boc) were synthesized by ring-opening polymerization (ROP) of TMC or CL and subsequently deprotected into the corresponding PTMC-NH2 and PCL-NH2. These functional homopolymers were used as macroinitiators for the ROP of gamma-benzyl-L-glutamate N-carboxyanhydride (BLG), consequently, giving the respective diblock copolymers PTMC-b-PBLG and PCL-b-PBLG in almost quantitative yields. The (co)polymers have been characterized by NMR and SEC analyses. DSC and IR studies confirmed the block structure of the copolymers and highlighted a phase separation between the rigid peptide (alpha-helix conformation) and the more flexible polyester segments. The self-assembly and the degradation behaviors of the copolymers depended on the nature of the polyester block and on the copolymer composition. Nanoparticles obtained from PBLG block copolymers were twice smaller (R-H < 100 nm) than those formed from PTMC and PCL homopolymers. Finally, their enzymatic degradation revealed that PTMC nanoparticles degraded faster than those made of PCL.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.subject.enDEGRADATION
dc.subject.enPOLY(EPSILON-CAPROLACTONE)
dc.subject.enDIBLOCK COPOLYMERS
dc.subject.enZINC-METAL
dc.subject.enPEPTIDE
dc.subject.enRING-OPENING POLYMERIZATION
dc.subject.enEPSILON-CAPROLACTONE
dc.subject.enTRIBLOCK COPOLYMERS
dc.subject.enN-CARBOXYANHYDRIDES
dc.subject.enINITIATORS
dc.title.enBiodegradable polycarbonate-b-polypeptide and polyester-b-polypeptide block copolymers: Synthesis and nanoparticle formation towards biomaterials
dc.typeArticle de revue
dc.identifier.doi10.1021/bm8001792
dc.subject.halChimie/Polymères
bordeaux.journalBiomacromolecules
bordeaux.page1924-1933
bordeaux.volume9
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue7
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-00338908
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00338908v1
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Biomacromolecules&amp;rft.date=2008&amp;rft.volume=9&amp;rft.issue=7&amp;rft.spage=1924-1933&amp;rft.epage=1924-1933&amp;rft.eissn=1525-7797&amp;rft.issn=1525-7797&amp;rft.au=LE%20HELLAYE,%20Maude&amp;FORTIN,%20Nicolas&amp;GUILLOTEAU,%20Julien&amp;SOUM,%20Alain&amp;LECOMMANDOUX,%20Sebastien&amp;rft.genre=article


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