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Mutations of SlCCS52A1 or SlCCS52A2 enhance cell division, but reveal distinct roles in plant and fruit development

hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorMAUXION, Jean-Philippe
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorBOLLIER, Norbert
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorHERNOULD, Michel
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorCHEVALIER, Christian
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorGONZALEZ, Nathalie
dc.date.conference2025-09-22
dc.description.abstractEnCell cycle progression is tightly regulated through the control of both the amount and activity of key regulators, CYCLIN-DEPENDENT KINASEs (CDKs) and CYCLINs. A critical aspect of this regulation involves the targeted degradation of these proteins by the 26S proteasome via ubiquitination mediated by the E3 ubiquitin ligase complex known as the Anaphase Promoting Complex/Cyclosome (APC/C). In plants, APC/C activity is modulated by CCS52 proteins, which act as activators enabling the selective degradation of target proteins.In our study, we identified a third CCS52 homologue in the tomato genome, SlCCS52A2, which shares high amino acid sequence similarity with SlCCS52A1. Building on previous research on SlCCS52A1 and the known partially redundant functions of the two AtCCS52A homologues in Arabidopsis, we performed a comparative phenotypic analysis of knockout lines for both SlCCS52A genes. Our aim was to clarify the role of SlCCS52A2.Our findings indicate that SlCCS52A1 and SlCCS52A2 in tomato retain conserved functions similar to their Arabidopsis counterparts but also exhibit distinct roles. Specifically, SlCCS52A1 is a positive regulator of endoreduplication and inhibits cell division in endoreduplicated cells, whereas SlCCS52A2 appears to play a key role in maintaining meristem function and inhibits cell division in the ovary.
dc.language.isoen
dc.title.enMutations of SlCCS52A1 or SlCCS52A2 enhance cell division, but reveal distinct roles in plant and fruit development
dc.typeAutre communication scientifique (congrès sans actes - poster - séminaire...)
dc.subject.halSciences du Vivant [q-bio]/Biologie du développement
bordeaux.conference.titleSolRub2025
bordeaux.countryIT
bordeaux.conference.cityTurin
bordeaux.peerReviewedoui
hal.identifierhal-05289732
hal.version1
hal.invitednon
hal.proceedingsnon
hal.conference.end2025-09-26
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-05289732v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.au=MAUXION,%20Jean-Philippe&BOLLIER,%20Norbert&HERNOULD,%20Michel&CHEVALIER,%20Christian&GONZALEZ,%20Nathalie&rft.genre=conference


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