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Peripheral artery disease.

dc.rights.licenseopenen_US
dc.contributor.authorABOYANS, Victor
dc.contributor.authorCANONICO, Mario Enrico
dc.contributor.authorCHASTAINGT, Lucie
dc.contributor.authorANAND, Sonia S
dc.contributor.authorBRODMANN, Marianne
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases [BMC]
dc.contributor.authorCOUFFINHAL, Thierry
dc.contributor.authorCRIQUI, Michael H
dc.contributor.authorDEBUS, Eike Sebastian
dc.contributor.authorMAZZOLAI, Lucia
dc.contributor.authorMCDERMOTT, Mary M
dc.contributor.authorBONACA, Marc P
dc.date.accessioned2025-09-29T10:32:32Z
dc.date.available2025-09-29T10:32:32Z
dc.date.issued2025-09-18
dc.identifier.issn2056-676Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/207679
dc.description.abstractEnPeripheral artery disease (PAD) is characterized by blockage of the arteries that supply the lower extremities, often occurring as a result of atherosclerosis and thrombosis. PAD affects approximately 230 million people worldwide, with a growing prevalence owing to population ageing and concomitant cardiovascular risk factors, including smoking, diabetes mellitus, hypertension and dyslipidaemia. Patients with PAD have an increased risk of major cardiovascular and limb events, and substantially poorer walking performance compared with those without PAD. The screening and identification of PAD involves clinical and imaging assessments of disease extent and severity and stratification of individual risk to ensure appropriate management. Patients with PAD should be treated with guideline-directed medical therapy (GDMT), including antithrombotic, lipid-lowering, glucose-lowering and anti-hypertensive therapies, and exercise therapies that aim to improve function as well as cardiovascular and limb outcomes. For patients with compromised limb viability, such as acute and chronic limb-threatening ischaemia, or severe functional impairment that does not improve with exercise training, lower extremity revascularization is recommended. Given the complexity of PAD management, a multidisciplinary vascular team is required to achieve the best individualized treatment. Further research efforts should focus on reducing ischaemic events and health disparities and on optimizing the implementation of GDMT and exercise therapy, as well as improving the quality of life in patients with PAD.
dc.language.isoENen_US
dc.subject.enHumans
dc.subject.enPeripheral Arterial Disease
dc.subject.enRisk Factors
dc.subject.enExercise Therapy
dc.subject.enQuality of Life
dc.title.enPeripheral artery disease.
dc.title.alternativeNat Rev Dis Primersen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41572-025-00651-0en_US
dc.subject.halSciences du Vivant [q-bio]en_US
dc.identifier.pubmed40968271en_US
bordeaux.journalNature reviews Disease primersen_US
bordeaux.page68en_US
bordeaux.volume11en_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires (BMC) - UMR 1034en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-05288457
hal.version1
hal.date.transferred2025-09-29T10:32:35Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20reviews%20Disease%20primers&rft.date=2025-09-18&rft.volume=11&rft.issue=1&rft.spage=68&rft.epage=68&rft.eissn=2056-676X&rft.issn=2056-676X&rft.au=ABOYANS,%20Victor&CANONICO,%20Mario%20Enrico&CHASTAINGT,%20Lucie&ANAND,%20Sonia%20S&BRODMANN,%20Marianne&rft.genre=article


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