Impact of socioeconomic individual and ecological factors on extreme diagnosis-to-treatment interval in diffuse large B-Cell lymphoma in the French real-world cohort REALYSA.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | CANTRELLE, Christelle | |
| dc.contributor.author | BELOT, Aurélien | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | MONNEREAU, Alain | |
| dc.contributor.author | BIJOU, Fontanet | |
| dc.contributor.author | ROSSI, Cédric | |
| dc.contributor.author | BOMMIER, Côme | |
| dc.contributor.author | HAFIRASSOU, Hadia Khebbeb | |
| dc.contributor.author | FOUILLET, Ludovic | |
| dc.contributor.author | GHESQUIÈRES, Hervé | |
| dc.contributor.author | YSEBAERT, Loic | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | LE GUYADER PEYROU, Sandra | |
| dc.date.accessioned | 2025-09-01T14:06:36Z | |
| dc.date.available | 2025-09-01T14:06:36Z | |
| dc.date.issued | 2025-10-01 | |
| dc.identifier.issn | 1877-783X | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/207549 | |
| dc.description.abstractEn | Diffuse large B-cell lymphoma (DLBCL) is an aggressive though potentially curable lymphoid malignancy requiring timely treatment initiation. We investigated the impact of individual socioeconomic status and home area-level (ecological) factors on the diagnosis-to-treatment interval (DTI) in DLBCL patients, focusing on extreme delays in a French real-world cohort (REALYSA). We analyzed patients with newly diagnosed DLBCL in the multicentric prospective cohort. DTI was defined as a duration in days between diagnosis confirmation and first-line therapy. Short and long DTIs (10th percentiles) were compared to intermediate DTI using multinomial models to identify factors associated with extreme DTIs. Socio-demographic data (including sex, education, employment, marital status, social support (SSQ6-score)…) and ecological characteristics (French deprivation index, local accessibility to general practitioners) were considered. Among 889 newly diagnosed DLBCL patients (median age 66 years, 49 % with aaIPI ≥1, 35 % with B-symptoms, 33 % with bulky disease), median DTI was 25 days (interquartile range: 15-39 days). The 10th- and 90th-percentile for extreme DTIs were 50 days respectively. In multivariable analysis, factors associated with short DTI included aaIPI (OR=3.03, CI95 %[1.44-6.41]), bulky disease (OR=3.06, CI95 %[1.68-5.58]), and B symptoms (OR=2.35, CI95 %[1.30-4.25]) - indicating expedited treatment for aggressive presentations. Conversely, factors associated with long DTI included older age (OR>80 y = 3.31, CI95 %[1.39-7.89]), being a blue-collar worker or farmer (OR=2.36, CI95 %[1.18-4.73]), or changing type of treatment facility between biopsy and initial treatment. In this large real-world cohort of newly diagnosed DLBCL patients, age, occupational status, and patients' pathway were linked to very long delays to treatment. Interventions to streamline DTIs, especially for older and/or blue-collar or farmer patients, and for those changing facility of treatment, are warranted to improve quality of care. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Diagnosis-to-treatment interval | |
| dc.subject.en | Diffuse large B-cell lymphoma | |
| dc.subject.en | Non-Hodgkin lymphoma | |
| dc.subject.en | Old patients | |
| dc.subject.en | Real-world data | |
| dc.subject.en | Socioeconomic factors | |
| dc.title.en | Impact of socioeconomic individual and ecological factors on extreme diagnosis-to-treatment interval in diffuse large B-Cell lymphoma in the French real-world cohort REALYSA. | |
| dc.title.alternative | Cancer Epidemiol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.canep.2025.102875 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 40816044 | en_US |
| bordeaux.journal | Cancer Epidemiology | en_US |
| bordeaux.page | 102875 | en_US |
| bordeaux.volume | 98 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | EPICENE_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Ligue Contre le Cancer | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-05233735 | |
| hal.version | 1 | |
| hal.date.transferred | 2025-09-01T14:06:39Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cancer%20Epidemiology&rft.date=2025-10-01&rft.volume=98&rft.spage=102875&rft.epage=102875&rft.eissn=1877-783X&rft.issn=1877-783X&rft.au=CANTRELLE,%20Christelle&BELOT,%20Aur%C3%A9lien&MONNEREAU,%20Alain&BIJOU,%20Fontanet&ROSSI,%20C%C3%A9dric&rft.genre=article |