Emotional dysfunction as a marker of bipolar disorders.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Institut Mondor de Recherche Biomédicale [IMRB] | |
| hal.structure.identifier | Fondation FondaMental [Créteil] | |
| dc.contributor.author | HENRY, Chantal | |
| hal.structure.identifier | University of Pittsburgh Medical Center [Pittsburgh, PA, États-Unis] [UPMC] | |
| dc.contributor.author | PHILLIPS, Mary | |
| dc.contributor.author | LEIBENLUFT, Ellen | |
| hal.structure.identifier | Centre hospitalier Charles Perrens [Bordeaux] | |
| hal.structure.identifier | Laboratoire de psychologie [LabPsy] | |
| dc.contributor.author | M'BAILARA, Katia
ORCID: 0000-0003-0211-3298 IDREF: 096257296 | |
| hal.structure.identifier | Institut Mondor de Recherche Biomédicale [IMRB] | |
| hal.structure.identifier | IMRB - "Neuropsychiatrie translationnelle" [Créteil] [U955 Inserm - UPEC] | |
| dc.contributor.author | HOUENOU, Josselin | |
| hal.structure.identifier | Institut Mondor de Recherche Biomédicale [IMRB] | |
| hal.structure.identifier | Fondation FondaMental [Créteil] | |
| hal.structure.identifier | Fédération Hospitalo-Universitaire de Médecine de Précision en Psychiatrie = Addiction And Psychiatry Transformation with Precision Medicine [Créteil, France] [FHU ADAPT] | |
| dc.contributor.author | LEBOYER, Marion | |
| dc.date.accessioned | 2025-07-11T14:16:25Z | |
| dc.date.available | 2025-07-11T14:16:25Z | |
| dc.date.issued | 2012-06-01 | |
| dc.identifier.issn | 1945-0508 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/207322 | |
| dc.description.abstractEn | Assessment of emotional reactivity, defined as rapid emotional responses to salient environmental events, has been neglected in mood disorders. This article reviews data showing the relevance of using emotional reactivity to better characterize bipolar mood episodes. We reviewed clinical data on emotional reactivity during all phases of bipolar disorders (euthymic, manic, mixed and depressive states) and brain-imaging, neurochemical, genetic studies related to emotional reactivity disturbances. Euthymic bipolar patients show mild abnormalities (hypersensitivity to emotional stimuli and higher arousability) in comparison to controls. Both manic and mixed states are characterized by a significant increase in emotional reactivity. Furthermore, emotional reactivity may discriminate between two types of bipolar depression, the first being characterized by emotional hypo-reactivity and global behavioral inhibition, the second by emotional hyper-reactivity. Brain-imaging studies can help to identify the underlying mechanisms involved in disturbances of emotional reactivity. Emotional reactivity can be used to refine more homogeneous pathophysiological subtypes of mood episodes. Future research should explore possible correlations between biomarkers, response to treatments and these clinical phenotypes. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Bipolar Disorder | |
| dc.subject.en | Case-Control Studies | |
| dc.subject.en | Emotions | |
| dc.subject.en | Humans | |
| dc.title.en | Emotional dysfunction as a marker of bipolar disorders. | |
| dc.title.alternative | Front Biosci (Elite Ed) | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.2741/e578 | en_US |
| dc.subject.hal | Sciences de l'Homme et Société/Psychologie | en_US |
| dc.identifier.pubmed | 22652673 | en_US |
| bordeaux.journal | Frontiers in Bioscience | en_US |
| bordeaux.page | 2622-30 | en_US |
| bordeaux.volume | 4 | en_US |
| bordeaux.hal.laboratories | Anciens laboratoires de l'Université de Bordeaux | en_US |
| bordeaux.issue | 7 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-05158651 | |
| hal.version | 1 | |
| hal.date.transferred | 2025-07-11T14:16:27Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20Bioscience&rft.date=2012-06-01&rft.volume=4&rft.issue=7&rft.spage=2622-30&rft.epage=2622-30&rft.eissn=1945-0508&rft.issn=1945-0508&rft.au=HENRY,%20Chantal&PHILLIPS,%20Mary&LEIBENLUFT,%20Ellen&M'BAILARA,%20Katia&HOUENOU,%20Josselin&rft.genre=article |
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