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The association between smoking status and aging cognitive trajectory accounting for bias in attrition

dc.rights.licenseopenen_US
dc.contributor.authorSTUCKWISCH, Rachel
dc.contributor.authorBENNETT, Aleena
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorROUANET, Anais
IDREF: 198306717
dc.contributor.authorEDWARDS, Lloyd J
dc.contributor.authorCROWE, Michael
dc.contributor.authorJUDD, Suzanne E
dc.contributor.authorLONG, D Leann
dc.date.accessioned2025-07-11T08:24:00Z
dc.date.available2025-07-11T08:24:00Z
dc.date.issued2025-05-20
dc.identifier.issn0002-9262en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/207312
dc.description.abstractEnStudies on the relationship between smoking and cognition yield conflicting results, potentially from survival bias. We examined the effect of smoking status on cognitive evolution, accounting for potential bias in attrition. We analyzed 21 216 Black and White participants from the REGARDS cohort study. In order to account for potential differential attrition, a sensitivity analysis compared the association between smoking status and age-sex-specific composite cognitive trajectories using linear mixed models, robust under missing at random assumption, and joint models, robust under the extended missing at random assumptions. Linear mixed model results indicated current smokers had lower overall composite cognitive scores compared to never smokers at baseline (-0.20, 95% confidence interval (CI): -0.23, -0.16) and at 14-years duration in the study (-0.26, 95% CI: -0.33, -0.20), also apparent when comparing current smokers to past smokers, and memory and verbal fluency composite scores. Joint modeling estimates yielded results similar to results from linear mixed models. Joint models are recommended as a potential means to investigate concerns about attrition, particularly in studies of factors associated with both cognition and mortality. This study provides further support that smoking is likely to have negative impacts on cognition.
dc.language.isoENen_US
dc.subject.enAttrition Bias
dc.subject.enCognition
dc.subject.enJoint Models
dc.subject.enSmoking
dc.title.enThe association between smoking status and aging cognitive trajectory accounting for bias in attrition
dc.title.alternativeAm J Epidemiolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/aje/kwaf107en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed40394218en_US
bordeaux.journalAmerican Journal of Epidemiologyen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-05157690
hal.version1
hal.date.transferred2025-07-11T08:24:03Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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