Cascade screening in familial hypercholesterolaemia is associated with earlier statin initiation and fewer cardiovascular events than opportunistic screening
| dc.rights.license | open | en_US |
| dc.contributor.author | MOURRE, Florian | |
| dc.contributor.author | GIORGI, Roch | |
| dc.contributor.author | CATTIEUW, Lauranne | |
| dc.contributor.author | GALLO, Antonio | |
| dc.contributor.author | MOULIN, Philippe | |
| dc.contributor.author | CHARRIERE, Sybil | |
| dc.contributor.author | AOUCHICHE, Karine | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | RIGALLEAU, Vincent | |
| dc.contributor.author | SCHIELE, Francois | |
| dc.contributor.author | SULTAN, Ariane | |
| dc.contributor.author | TOUNIAN, Patrick | |
| dc.contributor.author | VALERO, Rene | |
| dc.contributor.author | BELIARD, Sophie | |
| dc.date.accessioned | 2025-07-10T11:11:01Z | |
| dc.date.available | 2025-07-10T11:11:01Z | |
| dc.date.issued | 2025-05-06 | |
| dc.identifier.issn | 2047-4881 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/207301 | |
| dc.description.abstractEn | Aims The aim of this study is to assess whether the family cascade screening strategy for identifying patients with heterozygous familial hypercholesterolaemia (HeFH) is associated with a reduction in cardiovascular events compared with opportunistic screening strategies. Methods and results We retrospectively included 3232 patients, from the French FH registry, REFERCHOL, with a molecular diagnosis. We compared patients according to their screening strategy for HeFH: index cases (opportunistic screening) and cascade screening cases (patients diagnosed by cascade screening) on clinical and biological characteristics. We first compared patients according to screening modality using chi(2) and Student's t-tests and performed multivariate logistic regression to assess the association between screening strategy and the risk of cardiovascular events. We finally performed the same tests in an age- and sex-matched subpopulation. Compared with index cases (2106 patients), cascade screening cases (1126 patients) started statin use 14 years earlier [18.1 (interquartile range 12.5-29.1) years vs. 31.8 (19.7-42.4) years, P < 0.001] and 8.3% had a cardiovascular event prior to the first visit, vs. 26.5% in the index cases group (P < 0.001). In multivariate logistic regression, the cascade screening was independently associated with 51% less atherosclerotic cardiovascular disease (ASCVD) than the opportunistic screening. Age at statin initiation was also associated with ASCVD, with a higher adjusted odd ratio for higher age categories. In an age- and sex-matched analysis, cascade screening was no longer associated with ASCVD, but age at statin initiation remained. Conclusion The cascade screening strategy for familial hypercholesterolaemia is associated with 51% fewer cardiovascular events in genetically confirmed heFH probably due to an earlier age at treatment initiation. | |
| dc.description.sponsorship | CHOPIN - ANR-16-RHUS-0007 | en_US |
| dc.language.iso | EN | en_US |
| dc.subject.en | Cardiovascular disease | |
| dc.subject.en | Cascade screening | |
| dc.subject.en | Familial hypercholesterolaemia | |
| dc.subject.en | Familial hypercholesterolaemia screening | |
| dc.subject.en | Paediatric screening | |
| dc.title.en | Cascade screening in familial hypercholesterolaemia is associated with earlier statin initiation and fewer cardiovascular events than opportunistic screening | |
| dc.title.alternative | Eur J Prev Cardiol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1093/eurjpc/zwaf234 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 40326712 | en_US |
| bordeaux.journal | European Journal of Preventive Cardiology | en_US |
| bordeaux.page | zwaf234 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | LEHA_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
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