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Cognitive and neuroimaging outcome of very prodromal dementia with Lewy bodies

dc.rights.licenseopenen_US
dc.contributor.authorBLANC, Frederic
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBOUTELOUP, Vincent
dc.contributor.authorPAQUET, Claire
dc.contributor.authorCHUPIN, Marie
dc.contributor.authorPASQUIER, Florence
dc.contributor.authorGABELLE, Audrey
dc.contributor.authorCECCALDI, Mathieu
dc.contributor.authorDE SOUSA, Paulo Loureiro
dc.contributor.authorKROLAK-SALMON, Pierre
dc.contributor.authorDAVID, Renaud
dc.contributor.authorFISCHER, Clara
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
ORCID: 0000-0001-9482-5529
IDREF: 058586105
dc.contributor.authorWALLON, David
dc.contributor.authorMOREAUD, Olivier
dc.contributor.authorSAUVEE, Mathilde
dc.contributor.authorBELIN, Catherine
dc.contributor.authorROUBAUD, Claire
dc.contributor.authorBOTZUNG, Anne
dc.contributor.authorRAVIER, Alix
dc.contributor.authorDEMUYNCK, Catherine
dc.contributor.authorNAMER, Izzie
dc.contributor.authorHABERT, Marie-Odile
dc.contributor.authorBOUSIGES, Olivier
dc.contributor.authorSCHORR, Benoit
dc.contributor.authorMULLER, Candice
dc.contributor.authorPHILIPPI, Nathalie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCHENE, Genevieve
dc.contributor.authorCRETIN, Benjamin
dc.contributor.authorMANGIN, Jean-Francois
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDUFOUIL, Carole
dc.date.accessioned2025-07-10T10:46:21Z
dc.date.available2025-07-10T10:46:21Z
dc.date.issued2025-05-25
dc.identifier.issn2509-2723en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/207298
dc.description.abstractEnThe cognitive and neuroimaging evolution over the course of dementia with Lewy bodies (DLB) from prodromal stage - Pro-DLB (subjective (SCI) to mild cognitive impairment (MCI)) - is poorly understood. The aim of this study was to analyze from 5-year longitudinal data the trajectories of Pro-DLB patients. The "Lewy- MEMENTO" prospective clinical cohort recruited 773 patients for either SCI or MCI. The Pro-DLB group was compared to a group with prodromal Alzheimer's disease (Pro-AD), a group with "prodromal DLB and AD" (Pro-DLB + AD), and a group without prodromal DLB and AD (no symptom [NS]). We modeled the 5-year evolution of cognitive functions and the 2-year evolution of brain MRI volumetry on MRI and brain metabolism (FDG PET). The Pro-AD and Pro-DLB + AD groups had more cognitive and functional decline than the Pro-DLB and NS groups (P < .001). The Pro-DLB group had more cognitive decline than the NS group (P < .004). Incident dementia during the follow-up was higher in the Pro-AD (13.0 per 100 person-years) and Pro-DLB + AD (10.3) groups than in the Pro-DLB (1.02) and NS (0.44) groups (P < .001). The decline in the metabolism of the left orbitofrontal cortex was greater in the Pro-DLB + AD group. The volume decrease of hippocampi, entorhinal cortices, amygdalae, and left insula was higher in the Pro-AD and the pro-DLB + AD groups. Patients in the pro-DLB group had less cognitive, functional, brain volume, and metabolism decrease than patients in the Pro-AD and pro-DLB + AD groups. DLB would therefore be a less degenerative and more dysfunctional disease at the prodromal stage.
dc.language.isoENen_US
dc.subject.enAlzheimer’s disease
dc.subject.enDementia with Lewy bodies
dc.subject.enMild cognitive impairment
dc.subject.enProdromal
dc.subject.enSubjective cognitive impairment
dc.title.enCognitive and neuroimaging outcome of very prodromal dementia with Lewy bodies
dc.title.alternativeGeroscienceen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s11357-025-01701-xen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed40415136en_US
bordeaux.journalGeroScienceen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPHARES_BPHen_US
bordeaux.teamACTIVE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-05156286
hal.version1
hal.date.transferred2025-07-10T10:46:25Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=GeroScience&amp;rft.date=2025-05-25&amp;rft.eissn=2509-2723&amp;rft.issn=2509-2723&amp;rft.au=BLANC,%20Frederic&amp;BOUTELOUP,%20Vincent&amp;PAQUET,%20Claire&amp;CHUPIN,%20Marie&amp;PASQUIER,%20Florence&amp;rft.genre=article


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