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Associations of the LIBRA index with cognitive resilience to genetic susceptibility to dementia

dc.rights.licenseopenen_US
dc.contributor.authorWAGNER, Maude
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorNEUFFER, Jeanne
ORCID: 0000-0002-3667-6948
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLE GRAND, Quentin
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMISHRA, Aniket
dc.contributor.authorBERR, Claudine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPROUST LIMA, Cecile
ORCID: 0000-0002-9884-955X
IDREF: 114375747
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIERI, Cecilia
dc.date.accessioned2025-07-09T09:45:29Z
dc.date.available2025-07-09T09:45:29Z
dc.date.issued2025-05-20
dc.identifier.issn1476-6256en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/207280
dc.description.abstractEnThe role of lifestyle and health-related factors in dementia risk has been established. However, how a combination of modifiable risk factors, as reflected by the LIBRA (LIfestyle for BRAin health) index, contributes to cognitive resilience to genetic susceptibility to dementia (CRgen) remains unclear. We selected 6,774 Three-City study participants without dementia at baseline (mean age=74 years) and with ≥2 cognitive measures over time. Genetic risk was defined through ApoE-ε4 carriage alone (ε4-carriers) or combined with high AD-specific genetic risk scores beyond ApoE (ε4-carriers/GRS-high). To define CRgen, we modeled and compared the cognitive slopes of at-risk individuals to their demographically similar peers without genetic risk; at-risk individuals with the most preserved cognition were defined as resilient (ε4-carriers [n=237]; ε4-carrier/GRS-high [n=319]), and the least preserved as non-resilient (ε4-carriers [n=866]; ε4-carrier/GRS-high [n=1,249]). Lower LIBRA risk scores at baseline, denoting healthier lifestyle and reduced dementia risk, were linearly associated with greater odds of CRgen, both in ε4-carriers (odds ratio [OR]=1.11;95%CI=1.05-1.18) and ε4-carriers/GRS-high (OR=1.16;95%CI=1.11-1.22). When examining the LIBRA components, cognitive activity and coronary heart diseases history showed the strongest independent associations with CRgen (all P≤.01). Genetically susceptible older adults can develop cognitive resilience, which may be promoted by lifestyle modifications and health management simultaneously.
dc.language.isoENen_US
dc.subject.enApoe-Ε4
dc.subject.enCognitive Activity
dc.subject.enCognitive Decline
dc.subject.enCognitive Resilience
dc.subject.enGenetic Risk Score
dc.subject.enLatent Process Mixed Model
dc.subject.enLongitudinal Cohort Study
dc.title.enAssociations of the LIBRA index with cognitive resilience to genetic susceptibility to dementia
dc.title.alternativeAm J Epidemiolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/aje/kwaf108en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed40394208en_US
bordeaux.journalAmerican Journal of Epidemiologyen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-05153777
hal.version1
hal.date.transferred2025-07-09T09:45:32Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=American%20Journal%20of%20Epidemiology&rft.date=2025-05-20&rft.eissn=1476-6256&rft.issn=1476-6256&rft.au=WAGNER,%20Maude&NEUFFER,%20Jeanne&LE%20GRAND,%20Quentin&MISHRA,%20Aniket&BERR,%20Claudine&rft.genre=article


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