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A fast protocol for photodynamic therapy in exudative choroidal circumscribed hemangioma: Early laser irradiance after end of verteporfin infusion

dc.rights.licenseopenen_US
dc.contributor.authorDUBAR, Paul
dc.contributor.authorMATHIS, Thibaud
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHUCTEAU, Emilie
dc.contributor.authorTHARIAT, Juliette
dc.contributor.authorNHARI, Maxime
dc.contributor.authorMASCHI, Celia
dc.contributor.authorFABER, Carsten
dc.contributor.authorKIILGAARD, Jens Folke
dc.contributor.authorMOSCI, Carlo
dc.contributor.authorFAVARD, Catherine
dc.contributor.authorTICK, Sarah
dc.contributor.authorNGUYEN, Anh-Minh
dc.contributor.authorCAUJOLLE, Jean-Pierre
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELYFER, Marie-Noelle
dc.contributor.authorROSIER, Laurence
dc.date.accessioned2025-07-08T11:19:39Z
dc.date.available2025-07-08T11:19:39Z
dc.date.issued2025-05-05
dc.identifier.issn1755-3768en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/207267
dc.description.abstractEnPURPOSE: The aim of the study is to compare the risk of first-line photodynamic therapy (PDT) failure according to the PDT protocol performed in patients with exudative choroidal circumscribed hemangioma (CCH). METHODS: We retrospectively included patients from 11 European centres in France, Italy and Denmark. Two groups were established: patients treated with Standard Protocol PDT (SP-PDT) and patients treated with a 'Fast' Protocol PDT (FP-PDT), characterised by laser irradiation without delay after the end of the verteporfin infusion (8 min after start of infusion). We analysed groups on the risk of exudative CCH recurrence requiring a second line of treatment, defining the first-line PDT failure. RESULTS: A total of 111 patients were included in the study: 76 treated with the SP-PDT and 35 with the FP-PDT. First-line PDT failure was observed for 45 patients (59%) in the SP-PDT group and 9 patients (26%) in the FP-PDT group, with a median follow-up of 3.5 [1.7-6.7] years and 2.3 [0.8-3.9] years, respectively. Final best-corrected visual acuity (BCVA) improvement did not differ between groups (p = 0.49). A multivariate survival analysis including initial CCH thickness and initial BCVA was performed over a two-year follow-up period: FP-PDT as first-line treatment was significantly associated with a lower risk of PDT failure [HR = 0.27, 95%CI (0.11-0.65)]. CONCLUSION: FP-PDT shows encouraging results in the treatment of CCHs, as it is associated with a lower risk of PDT failure. It may therefore represent an interesting avenue for optimised PDT parameters, although these results need to be confirmed by randomised trials.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enChoroidal Diseases
dc.subject.enChoroidal Tumour
dc.subject.enCircumscribed Choroidal Hemangioma
dc.subject.enLaser Protocol
dc.subject.enOnco‐Ophthalmology
dc.subject.enPhotodynamic Therapy
dc.subject.enRetina
dc.subject.enVerteporfin
dc.title.enA fast protocol for photodynamic therapy in exudative choroidal circumscribed hemangioma: Early laser irradiance after end of verteporfin infusion
dc.title.alternativeActa Ophthalmolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/aos.17513en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed40322789en_US
bordeaux.journalActa Ophthalmologicaen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-05150719
hal.version1
hal.date.transferred2025-07-08T11:19:43Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Acta%20Ophthalmologica&rft.date=2025-05-05&rft.eissn=1755-3768&rft.issn=1755-3768&rft.au=DUBAR,%20Paul&MATHIS,%20Thibaud&HUCTEAU,%20Emilie&THARIAT,%20Juliette&NHARI,%20Maxime&rft.genre=article


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