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A Multi-Omics Approach Reveals Novel Regulators of Plasma Factor V Levels: highlight on CLEC4M as a Clearance Receptor

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMUNSCH, Gaelle
dc.contributor.authorMOHAPATRA, Adarsh
dc.contributor.authorVAN HYLCKAMA VLIEG, Astrid
dc.contributor.authorKLEBER, Marcus E
dc.contributor.authorMARTINEZ-PEREZ, Angel
dc.contributor.authorLE, Ngoc-Quynh
dc.contributor.authorHINDBERG, Kristian Dalsbo
dc.contributor.authorDUSART, Philip J
dc.contributor.authorGERMAIN, Marine
dc.contributor.authorTHIBORD, Florian
dc.contributor.authorDELEUZE, Jean-Francois
dc.contributor.authorDELGADO, Graciela E
dc.contributor.authorGOUMIDI, Louisa
dc.contributor.authorSUCHON, Pierre
dc.contributor.authorSAUT, Noemie
dc.contributor.authorSOUTO, Juan Carlos
dc.contributor.authorBUTLER, Lynn
dc.contributor.authorSORIA, Jose Manuel
dc.contributor.authorHANSEN, John-Bjarne
dc.contributor.authorMARZ, Winfried
dc.contributor.authorROSENDAAL, Frits R
dc.contributor.authorCASTOLDI, Elisabetta
dc.contributor.authorPEIRETTI, Franck
dc.contributor.authorSABATER-LLEAL, Maria
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTREGOUET, David-Alexandre
dc.contributor.authorMORANGE, Pierre-Emmanuel
dc.date.accessioned2025-07-08T09:17:05Z
dc.date.available2025-07-08T09:17:05Z
dc.date.issued2025-05-13
dc.identifier.issn1528-0020en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/207261
dc.description.abstractEnCoagulation factor V (FV) is a key protein in maintaining the hemostatic balance, with abnormal plasma levels associated with both thrombotic and hemorrhagic conditions. We propose a comprehensive bioinformatic analysis integrating large scale proteogenomics and transcriptomic data from original and public datasets. We identify a biological fingerprint of 26 new proteins and loci involved in the regulation of plasma FV levels. Furthermore, the mRNA expression levels of 10 of these components show strong correlation in liver. In addition, we provide experimental evidence for the involvement of one of the newly identified players (CLEC4M) in the clearance of FV. This work opens new avenues for a better understanding of the physiological processes involved in thrombotic and bleeding disorders.
dc.language.isoENen_US
dc.title.enA Multi-Omics Approach Reveals Novel Regulators of Plasma Factor V Levels: highlight on CLEC4M as a Clearance Receptor
dc.title.alternativeBlooden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1182/blood.2024027006en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed40359434en_US
bordeaux.journalBlooden_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-05150213
hal.version1
hal.date.transferred2025-07-08T09:17:08Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Blood&rft.date=2025-05-13&rft.eissn=1528-0020&rft.issn=1528-0020&rft.au=MUNSCH,%20Gaelle&MOHAPATRA,%20Adarsh&VAN%20HYLCKAMA%20VLIEG,%20Astrid&KLEBER,%20Marcus%20E&MARTINEZ-PEREZ,%20Angel&rft.genre=article


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