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Histoplasma antigenuria prevalence in patients with advanced HIV disease in Côte d'Ivoire: a prospective trial ancillary study

dc.rights.licenseopenen_US
dc.contributor.authorSTURNY-LECLERE, Aude
dc.contributor.authorFRANCOISE, Ugo
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorBADJE, Anani
dc.contributor.authorGARCIA-HERMOSO, Dea
dc.contributor.authorAKA, Cyrielle
dc.contributor.authorMENAN, Herve
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorGABILLARD, Delphine
dc.contributor.authorMUZOORA, Conrad K
dc.contributor.authorBONNET, Maryline
dc.contributor.authorBLANC, Francois-Xavier
dc.contributor.authorLORTHOLARY, Olivier
dc.contributor.authorALANIO, Alexandre
dc.contributor.authorADENIS, Antoine A
dc.contributor.authorLAUREILLARD, Didier
dc.contributor.authorLANTERNIER, Fanny
dc.date.accessioned2025-07-08T09:12:58Z
dc.date.available2025-07-08T09:12:58Z
dc.date.issued2025-05-16
dc.identifier.issn1537-6591en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/207259
dc.description.abstractEnBACKGROUND: Despite tuberculosis being a well-known concern in advanced HIV patients, the STATIS trial, which focused on its management, highlighted significant mortality rates. Histoplasmosis, a fungal disease endemic in sub-Saharan Africa, presents with similar clinical manifestations as of tuberculosis. Therefore, it may be prevalent and potentially responsible for deaths in advanced HIV patients in this region. We conducted an ancillary study of the STATIS trial to provide the first prevalence estimates of histoplasmosis among individuals with advanced HIV in Côte d'Ivoire. METHODS: We analyzed urine samples from patients previously enrolled in the STATIS trial in Côte d'Ivoire. These ambulatory patients with newly diagnosed HIV infection, CD4 + T-cell counts <100/µL and eligible to ART were randomized to receive either systematic or test-guided tuberculosis treatment. We performed Histoplasma Antigen Enzyme Immunoassay (EIA) on their urine samples. RESULTS: The prevalence of Histoplasma antigenuria was 68/280 (24.3%; 95%CI: 19.5-29.8), including 52/280 (18.6%, 95%CI: 14.3-23.7) symptomatic patients. Of 22 tuberculosis cases documented at inclusion, 8 (36.4%) also had Histoplasma antigenuria. In patients who died within the 48-week follow-up, the prevalence of Histoplasma antigenuria was 15/42 (35.7%, 95%CI: 22.0-52.0), compared with 22.3% (95%CI: 17.3-28.2) in those surviving. These survivors had a higher body mass index, CD4 + T-cell count, hemoglobin and platelet count than those who died. CONCLUSIONS: The prevalence of Histoplasma antigenuria was comparable to that of tuberculosis, and histoplasmosis was potentially responsible for preventable deaths. Prospective studies are needed to confirm these findings and promote screening strategies in sub-Saharan Africa.
dc.language.isoENen_US
dc.subject.enAfrica
dc.subject.enAntigen
dc.subject.enEIA
dc.subject.enHIV
dc.subject.enHistoplasmosis
dc.subject.enprevalence
dc.title.enHistoplasma antigenuria prevalence in patients with advanced HIV disease in Côte d'Ivoire: a prospective trial ancillary study
dc.title.alternativeClin Infect Disen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/cid/ciaf237en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed40377456en_US
bordeaux.journalClinical Infectious Diseasesen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamGHIGS_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut de Recherche pour le Développementen_US
hal.identifierhal-05150176
hal.version1
hal.date.transferred2025-07-08T09:13:01Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Clinical%20Infectious%20Diseases&amp;rft.date=2025-05-16&amp;rft.eissn=1537-6591&amp;rft.issn=1537-6591&amp;rft.au=STURNY-LECLERE,%20Aude&amp;FRANCOISE,%20Ugo&amp;BADJE,%20Anani&amp;GARCIA-HERMOSO,%20Dea&amp;AKA,%20Cyrielle&amp;rft.genre=article


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