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Molecular and functional mapping of the neuroendocrine hypothalamus: a new era begins

dc.rights.licenseopenen_US
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorLEE, Thomas H.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorNICOLAS, Jean Charles
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorQUARTA, Carmelo
dc.date.accessioned2025-07-02T11:35:24Z
dc.date.available2025-07-02T11:35:24Z
dc.date.issued2024-11
dc.identifier.issn0391-4097en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/207181
dc.description.abstractEnBackground: Recent advances in neuroscience tools for single-cell molecular profiling of brain neurons have revealed an enormous spectrum of neuronal subpopulations within the neuroendocrine hypothalamus, highlighting the remarkable molecular and cellular heterogeneity of this brain area. Rationale: Neuronal diversity in the hypothalamus reflects the high functional plasticity of this brain area, where multiple neuronal populations flexibly integrate a variety of physiological outputs, including energy balance, stress and fertility, through crosstalk mechanisms with peripheral hormones. Intrinsic functional heterogeneity is also observed within classically ‘defined’ subpopulations of neuroendocrine neurons, including subtypes with distinct neurochemical signatures, spatial organisation and responsiveness to hormonal cues. Aim: The aim of this review is to critically evaluate past and current research on the functional diversity of hypothalamic neuroendocrine neurons and their plasticity. It focuses on how this neuronal plasticity in this brain area relates to metabolic control, feeding regulation and interactions with stress and fertility-related neural circuits. Conclusion: Our analysis provides an original framework for improving our understanding of the hypothalamic regulation of hormone function and the development of neuroendocrine diseases. © The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE) 2024.
dc.language.isoENen_US
dc.subject.enEnergy balance
dc.subject.enFertility
dc.subject.enHypothalamus
dc.subject.enNeuroendocrinology
dc.subject.enNeuronal heterogeneity
dc.subject.enStress
dc.title.enMolecular and functional mapping of the neuroendocrine hypothalamus: a new era begins
dc.title.alternativeJ Endocrinol Investen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s40618-024-02411-5en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed38878127en_US
bordeaux.journalJournal of Endocrinological Investigationen_US
bordeaux.page2627 – 2648en_US
bordeaux.volume47en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue11en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPhysiopathologie de l'équilibre énergétique et obésitéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-05140280
hal.version1
hal.date.transferred2025-07-02T11:35:26Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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