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Antiobesity effects of intestinal gluconeogenesis are mediated by the brown adipose tissue sympathetic nervous system
| dc.rights.license | open | en_US |
| dc.contributor.author | VILY-PETIT, Justine | |
| dc.contributor.author | SOTY-ROCA, Maud | |
| dc.contributor.author | SILVA, Marine | |
| dc.contributor.author | MICOUD, Manon | |
| dc.contributor.author | EVRARD, Félicie | |
| dc.contributor.author | BRON, Clara | |
| dc.contributor.author | RAFFIN, Margaux | |
| dc.contributor.author | BEIROA, Daniel | |
| dc.contributor.author | NOGUEIRAS, Rubén | |
| dc.contributor.author | ROUSSEL, Damien | |
| dc.contributor.author | GAUTIER-STEIN, Amandine | |
| dc.contributor.author | RAJAS, Fabienne | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | COTA, Daniela | |
| dc.contributor.author | MITHIEUX, Gilles | |
| dc.date.accessioned | 2025-07-02T11:19:37Z | |
| dc.date.available | 2025-07-02T11:19:37Z | |
| dc.date.issued | 2024-04 | |
| dc.identifier.issn | 1930-7381 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/207180 | |
| dc.description.abstractEn | Objective: Intestinal gluconeogenesis (IGN), via the initiation of a gut-brain nervous circuit, accounts for the metabolic benefits linked to dietary proteins or fermentable fiber in rodents and has been positively correlated with the rapid amelioration of body weight after gastric bypass surgery in humans with obesity. In particular, the activation of IGN moderates the development of hepatic steatosis accompanying obesity. In this study, we investigated the specific effects of IGN on adipose tissue metabolism, independent of its induction by nutritional manipulation. Methods: We used two transgenic mouse models of suppression or overexpression of G6pc1, the catalytic subunit of glucose-6 phosphatase, which is the key enzyme of endogenous glucose production specifically in the intestine. Results: Under a hypercaloric diet, mice overexpressing IGN showed lower adiposity and higher thermogenic capacities than wild-type mice, featuring marked browning of white adipose tissue (WAT) and prevention of the whitening of brown adipose tissue (BAT). Sympathetic denervation restricted to BAT caused the loss of the antiobesity effects associated with IGN. Conversely, IGN-deficient mice exhibited an increase in adiposity under a standard diet, which was associated with decreased expression of markers of thermogenesis in both BAT and WAT. Conclusions: IGN is sufficient to activate the sympathetic nervous system and prevent the expansion and the metabolic alterations of BAT and WAT metabolism under a high-calorie diet, thereby preventing the development of obesity. These data increase knowledge of the mechanisms of weight reduction in gastric bypass surgery and pave the way for new approaches to prevent or cure obesity. © 2024 The Obesity Society. | |
| dc.description.sponsorship | Le Signal Glucose Portal protège du Diabète | en_US |
| dc.language.iso | EN | en_US |
| dc.subject.en | Humans | |
| dc.subject.en | Controlled Study | |
| dc.subject.en | Genetics | |
| dc.subject.en | Animal Experiment | |
| dc.subject.en | Mouse | |
| dc.subject.en | Immunohistochemistry | |
| dc.subject.en | Complication | |
| dc.subject.en | Nuclear Magnetic Resonance Imaging | |
| dc.subject.en | Metabolism | |
| dc.subject.en | Cytokine Release | |
| dc.subject.en | Western Blotting | |
| dc.subject.en | Histopathology | |
| dc.subject.en | Obesity | |
| dc.subject.en | Animal Model | |
| dc.subject.en | Animal Tissue | |
| dc.subject.en | Fatty Liver | |
| dc.subject.en | Electron Microscopy | |
| dc.subject.en | Lipid Storage | |
| dc.subject.en | Transmission Electron Microscopy | |
| dc.subject.en | Energy Metabolism | |
| dc.subject.en | Transgenic Mouse | |
| dc.subject.en | Oxidative Phosphorylation | |
| dc.subject.en | Fat Mass | |
| dc.subject.en | Adrenergic System | |
| dc.subject.en | Sympathetic Nervous System | |
| dc.subject.en | Energy Expenditure | |
| dc.subject.en | Thermogenesis | |
| dc.subject.en | Adipose Tissue | |
| dc.subject.en | Antiobesity Activity | |
| dc.subject.en | Brown Adipose Tissue | |
| dc.subject.en | Gluconeogenesis | |
| dc.subject.en | Glucose 6 Phosphatase | |
| dc.subject.en | High Calorie Diet | |
| dc.subject.en | Intestine Function | |
| dc.subject.en | Tissue Metabolism | |
| dc.title.en | Antiobesity effects of intestinal gluconeogenesis are mediated by the brown adipose tissue sympathetic nervous system | |
| dc.title.alternative | Obesity (Silver Spring) | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1002/oby.23985 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 38311801 | en_US |
| bordeaux.journal | Obesity | en_US |
| bordeaux.page | 710 – 722 | en_US |
| bordeaux.volume | 32 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.issue | 4 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | Physiopathologie de l'équilibre énergétique et obésité | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Obesity&rft.date=2024-04&rft.volume=32&rft.issue=4&rft.spage=710%20%E2%80%93%20722&rft.epage=710%20%E2%80%93%20722&rft.eissn=1930-7381&rft.issn=1930-7381&rft.au=VILY-PETIT,%20Justine&SOTY-ROCA,%20Maud&SILVA,%20Marine&MICOUD,%20Manon&EVRARD,%20F%C3%A9licie&rft.genre=article |
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