| dc.rights.license | open | en_US |
| hal.structure.identifier | Hôpital Lariboisière-Fernand-Widal [APHP] | |
| hal.structure.identifier | Marqueurs cardiovasculaires en situation de stress [MASCOT (UMR_S_942 / U942)] | |
| dc.contributor.author | DILLINGER, Jean-Guillaume | |
| hal.structure.identifier | Hôpital Lariboisière-Fernand-Widal [APHP] | |
| hal.structure.identifier | Marqueurs cardiovasculaires en situation de stress [MASCOT (UMR_S_942 / U942)] | |
| dc.contributor.author | PEZEL, Théo | |
| hal.structure.identifier | Centre Hospitalier Universitaire de Toulouse [CHU Toulouse] | |
| dc.contributor.author | DELMAS, Clément | |
| hal.structure.identifier | Institut Coeur Poumon [CHU Lille] | |
| dc.contributor.author | SCHURTZ, Guillaume | |
| hal.structure.identifier | Centre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg] | |
| dc.contributor.author | TRIMAILLE, Antonin | |
| hal.structure.identifier | Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA] | |
| dc.contributor.author | PILIERO, Nicolas | |
| hal.structure.identifier | Centre hospitalier universitaire de Poitiers = Poitiers University Hospital [CHU de Poitiers [La Milétrie]] | |
| dc.contributor.author | BOULETI, Claire | |
| hal.structure.identifier | Centre Hospitalier Universitaire de Nîmes [CHU Nîmes] | |
| dc.contributor.author | LATTUCA, Benoit | |
| hal.structure.identifier | Centre Hospitalier Henri Duffaut (Avignon) | |
| dc.contributor.author | ANDRIEU, Stéphane | |
| hal.structure.identifier | Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] [CHU de Martinique] | |
| dc.contributor.author | FABRE, Julien | |
| hal.structure.identifier | Centre hospitalier Félix-Guyon [Saint-Denis, La Réunion] | |
| dc.contributor.author | ROSSANALY VASRAM, Reza | |
| hal.structure.identifier | Clinique Ambroise Paré - ELSAN [CAPE] | |
| dc.contributor.author | DIB, Jean-Claude | |
| hal.structure.identifier | CHU Limoges | |
| dc.contributor.author | ABOYANS, Victor | |
| hal.structure.identifier | CHU Rouen | |
| hal.structure.identifier | Endothélium, valvulopathies et insuffisance cardiaque [EnVI] | |
| dc.contributor.author | FAUVEL, Charles | |
| hal.structure.identifier | Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] [PhyMedExp] | |
| hal.structure.identifier | Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier] | |
| dc.contributor.author | ROUBILLE, François | |
| hal.structure.identifier | Hôpital Haut-Lévêque [CHU Bordeaux] | |
| hal.structure.identifier | Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB] | |
| dc.contributor.author | GERBAUD, Edouard | |
| hal.structure.identifier | Centre Hospitalier Intercommunal André Grégoire [Montreuil] [CHI André Gregoire] | |
| dc.contributor.author | BOCCARA, Albert | |
| hal.structure.identifier | Hôpital Européen Georges Pompidou [APHP] [HEGP] | |
| hal.structure.identifier | Université Paris Cité [UPCité] | |
| dc.contributor.author | PUYMIRAT, Etienne | |
| hal.structure.identifier | Hôpital Lariboisière-Fernand-Widal [APHP] | |
| hal.structure.identifier | Marqueurs cardiovasculaires en situation de stress [MASCOT (UMR_S_942 / U942)] | |
| dc.contributor.author | TOUPIN, Solenn | |
| hal.structure.identifier | Hôpital Lariboisière-Fernand-Widal [APHP] | |
| dc.contributor.author | VICAUT, Eric | |
| hal.structure.identifier | Hôpital Lariboisière-Fernand-Widal [APHP] | |
| hal.structure.identifier | Marqueurs cardiovasculaires en situation de stress [MASCOT (UMR_S_942 / U942)] | |
| dc.contributor.author | HENRY, Patrick | |
| dc.date.accessioned | 2025-06-16T12:17:37Z | |
| dc.date.available | 2025-06-16T12:17:37Z | |
| dc.date.issued | 2024-01-01 | |
| dc.identifier.issn | 2589-5370 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/206921 | |
| dc.description.abstractEn | Background: Smoking cigarettes produces carbon monoxide (CO), which can reduce the oxygen-carrying capacity of the blood. We aimed to determine whether elevated expiratory CO levels would be associated with a worse prognosis in smokers presenting with acute cardiac events.Methods: From 7 to 22 April 2021, expiratory CO levels were measured in a prospective registry including all consecutive patients admitted for acute cardiac event in 39 centres throughout France. The primary outcome was 1-year all-cause death. Initial in-hospital major adverse cardiac events (MAE; death, resuscitated cardiac arrest and cardiogenic shock) were also analysed. The study was registered at ClinicalTrials.gov (NCT05063097).Findings: Among 1379 patients (63 ± 15 years, 70% men), 368 (27%) were active smokers. Expiratory CO levels were significantly raised in active smokers compared to non-smokers. A CO level >11 parts per million (ppm) found in 94 (25.5%) smokers was associated with a significant increase in death (14.9% for CO > 11 ppm vs. 2.9% for CO ≤ 11 ppm; p < 0.001). Similar results were found after adjustment for comorbidities (hazard ratio [HR] [95% confidence interval (CI)]): 5.92 [2.43-14.38]) or parameters of in-hospital severity (HR 6.09, 95% CI [2.51-14.80]) and propensity score matching (HR 7.46, 95% CI [1.70-32.8]). CO > 11 ppm was associated with a significant increase in MAE in smokers during initial hospitalisation after adjustment for comorbidities (odds ratio [OR] 15.75, 95% CI [5.56-44.60]) or parameters of in-hospital severity (OR 10.67, 95% CI [4.06-28.04]). In the overall population, CO > 11 ppm but not smoking was associated with an increased rate of all-cause death (HR 4.03, 95% CI [2.33-6.98] and 1.66 [0.96-2.85] respectively).Interpretation: Elevated CO level is independently associated with a 6-fold increase in 1-year death and 10-fold in-hospital MAE in smokers hospitalized for acute cardiac events. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Acute cardiac events | |
| dc.subject.en | Carbon monoxide | |
| dc.subject.en | Cardiovascular events | |
| dc.subject.en | Death | |
| dc.subject.en | Smoking | |
| dc.subject.en | Tobacco | |
| dc.title.en | Carbon monoxide and prognosis in smokers hospitalised with acute cardiac events: a multicentre, prospective cohort study | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.eclinm.2023.102401 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio] | en_US |
| bordeaux.journal | EClinicalMedicine | en_US |
| bordeaux.page | 102401 | en_US |
| bordeaux.volume | 67 | en_US |
| bordeaux.hal.laboratories | Centre de Recherche Cardio-Thoracique de Bordeaux (CRCTB) - U1045 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-04413845 | |
| hal.version | 1 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=EClinicalMedicine&rft.date=2024-01-01&rft.volume=67&rft.spage=102401&rft.epage=102401&rft.eissn=2589-5370&rft.issn=2589-5370&rft.au=DILLINGER,%20Jean-Guillaume&PEZEL,%20Th%C3%A9o&DELMAS,%20Cl%C3%A9ment&SCHURTZ,%20Guillaume&TRIMAILLE,%20Antonin&rft.genre=article | |
