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Blood immunophenotyping of multiple sclerosis patients at diagnosis identifies a classical monocyte subset associated to disease evolution

dc.rights.licenseopenen_US
dc.contributor.authorRODRIGUEZ, Stéphane
dc.contributor.authorCOULOUME, Laura
dc.contributor.authorFERRANT, Juliette
dc.contributor.authorVINCE, Nicolas
dc.contributor.authorMANDON, Marion
dc.contributor.authorJEAN, Rachel
dc.contributor.authorMONVOISIN, Celine
dc.contributor.authorLEONARD, Simon
dc.contributor.authorLE GALLOU, Simon
dc.contributor.authorSILVA, Nayane S. B.
dc.contributor.authorBOURGUIBA-HACHEMI, Sonia
dc.contributor.authorLAPLAUD, David
dc.contributor.authorGARCIA, Alexandra
dc.contributor.authorCASEY, Romain
dc.contributor.authorZEPHIR, Helene
dc.contributor.authorKERBRAT, Anne
dc.contributor.authorEDAN, Gilles
dc.contributor.authorLEPAGE, Emmanuelle
dc.contributor.authorTHOUVENOT, Eric
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorRUET, Aurelie
dc.contributor.authorMATHEY, Guillaume
dc.contributor.authorGOURRAUD, Pierre-Antoine
dc.contributor.authorTARTE, Karin
dc.contributor.authorDELALOY, Celine
dc.contributor.authorAMÉ, Patricia
dc.contributor.authorROUSSEL, Mikael
dc.contributor.authorMICHEL, Laure
dc.date.accessioned2025-06-11T08:24:59Z
dc.date.available2025-06-11T08:24:59Z
dc.date.issued2025-01-08
dc.identifier.issn1664-3224en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/206870
dc.description.abstractEnIntroduction: Myeloid cells trafficking from the periphery to the central nervous system are key players in multiple sclerosis (MS) through antigen presentation, cytokine secretion and repair processes. Methods: Combination of mass cytometry on blood cells from 60 MS patients at diagnosis and 29 healthy controls, along with single cell RNA sequencing on paired blood and cerebrospinal fluid (CSF) samples from 5 MS patients were used for myeloid cells detailing. Results: Myeloid compartment study demonstrated an enrichment of a peculiar classical monocyte population in 22% of MS patients at the time of diagnosis. Notably, this patients’ subgroup exhibited a more aggressive disease phenotype two years post-diagnosis. This monocytic population, detected in both the CSF and blood, was characterized by CD206, CD209, CCR5 and CCR2 expression, and was found to be more frequent in MS patients carrying the HLA-DRB1*15:01 allele. Furthermore, pathways analysis predicted that these cells had antigen presentation capabilities coupled with pro-inflammatory phenotype. Discussion: Altogether, these results point toward the amplification of a specific and pathogenic myeloid cell subset in MS patients with genetic susceptibilities.
dc.description.sponsorshipObservatoire Français de la Sclérose en Plaques - ANR-10-COHO-0002en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enMultiple sclerosis
dc.subject.enCerebrospinal fluid
dc.subject.enClassical monocyte
dc.subject.enDisability
dc.subject.enAntigen presentation
dc.title.enBlood immunophenotyping of multiple sclerosis patients at diagnosis identifies a classical monocyte subset associated to disease evolution
dc.title.alternativeFront Immunolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3389/fimmu.2024.1494842en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed39845960en_US
bordeaux.journalFrontiers in immunologyen_US
bordeaux.volume15en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamRelations glie-neuroneen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20immunology&rft.date=2025-01-08&rft.volume=15&rft.eissn=1664-3224&rft.issn=1664-3224&rft.au=RODRIGUEZ,%20St%C3%A9phane&COULOUME,%20Laura&FERRANT,%20Juliette&VINCE,%20Nicolas&MANDON,%20Marion&rft.genre=article


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