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Trajectories of Pontine Volume in Patients with Multiple System Atrophy

dc.rights.licenseopenen_US
dc.contributor.authorKAWABATA, Kazuya
dc.contributor.authorKRISMER, Florian
dc.contributor.authorITO, Mizuki
dc.contributor.authorHARA, Kazuhiro
dc.contributor.authorBAGARINAO, Epifanio
dc.contributor.authorBELIVEAU, Vincent
dc.contributor.authorPERAN, Patrice
dc.contributor.authorARRIBARAT, Germain
dc.contributor.authorTRAON, Anne Pavy-Le
dc.contributor.authorMEISSNER, Wassilios G
dc.contributor.authorFOUBERT-SAMIER, Alexandra
dc.contributor.authorFABBRI, Margherita
dc.contributor.authorGORDON, Mark Forrest
dc.contributor.authorOGURA, Aya
dc.contributor.authorKATSUNO, Masahisa
dc.contributor.authorRASCOL, Olivier
dc.contributor.authorSCHERFLER, Christoph
dc.contributor.authorSEPPI, Klaus
dc.contributor.authorWATANABE, Hirohisa
dc.contributor.authorPOEWE, Werner
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIER FOUBERT, Alexandra
dc.date.accessioned2025-05-28T07:58:52Z
dc.date.available2025-05-28T07:58:52Z
dc.date.issued2025-04-02
dc.identifier.issn1531-8257en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/206765
dc.description.abstractEnOBJECTIVES: To investigate trajectories of regional brain volume changes in multiple system atrophy (MSA) and their potential utility as surrogate markers of disease progression in the cerebellar subtype (MSA-C). BACKGROUND: Reliable biomarkers for tracking disease progression in MSA are urgently needed. Although several studies have explored neuroimaging markers, imaging measures that are reliable and reproducible at the individual-level are lacking. METHODS: Longitudinal three-dimensional (3D)-T1 images from multiple cohorts of 21 subjects with probable MSA-C, 19 with probable MSA-parkinsonian subtype (MSA-P), 113 with Parkinson's disease, and 227 healthy controls were processed using the FreeSurfer longitudinal pipeline. Extracted volumes were assessed for individual longitudinal trajectories, intra-individual variability, and pontine regional volume decline. RESULTS: Pontine volumes showed lower intra-individual variability in measurements compared with other infratentorial brain regions. All probable MSA-C patients exhibited a decline in pontine volume, ranging from -3.6% to -16.8% per year (mean: -9.1%), falling more than two standard deviations below the mean of healthy controls. In MSA-C, the temporal dynamics of pontine volumes exhibited nonlinear changes, characterized by progressive atrophy in the earlier period of the disease, followed by a pre-plateau phase associated with advanced disability in the later period. Predictive modeling suggests that pontine atrophy may begin before symptom onset of MSA-C. CONCLUSIONS: Pontine volume is a sensitive marker of disease progression, exhibiting a nonlinear decline with low intra-individual variability in measurements and greater volume loss in the earlier stages, reaching a pre-plateau phase in the later stages with advanced disability. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.title.enTrajectories of Pontine Volume in Patients with Multiple System Atrophy
dc.title.alternativeMov Disorden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/mds.30182en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed40172076en_US
bordeaux.journalMovement Disordersen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamACTIVE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-05087877
hal.version1
hal.date.transferred2025-05-28T07:58:56Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Movement%20Disorders&rft.date=2025-04-02&rft.eissn=1531-8257&rft.issn=1531-8257&rft.au=KAWABATA,%20Kazuya&KRISMER,%20Florian&ITO,%20Mizuki&HARA,%20Kazuhiro&BAGARINAO,%20Epifanio&rft.genre=article


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