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Selected social and lifestyle correlates of brain health markers: the Cross-Cohort Collaboration Consortium

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGRASSET, Leslie
dc.contributor.authorBIS, Joshua C
dc.contributor.authorFRENZEL, Stefan
dc.contributor.authorKOJIS, Daniel
dc.contributor.authorSIMINO, Jeannette
dc.contributor.authorYAQUB, Amber
dc.contributor.authorBEISER, Alexa
dc.contributor.authorBERR, Claudine
dc.contributor.authorBRESSLER, Jan
dc.contributor.authorBULOW, Robin
dc.contributor.authorDECARLI, Charles S
dc.contributor.authorFOHNER, Alison E
dc.contributor.authorHARRINGTON, Laura B
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
dc.contributor.authorIKRAM, M Arfan
dc.contributor.authorLEMAITRE, Rozenn N
dc.contributor.authorLOPEZ, Oscar L
dc.contributor.authorLONGSTRETH, W T Jr
dc.contributor.authorNEITZEL, Julia
dc.contributor.authorODDEN, Michelle C
dc.contributor.authorPALTA, Priya
dc.contributor.authorSCHMIDT, Carsten O
dc.contributor.authorTALLURI, Rajesh
dc.contributor.authorVERNOOIJ, Meike W
dc.contributor.authorVOLZKE, Henry
dc.contributor.authorVOORTMAN, Trudy
dc.contributor.authorWHALEN, Quest
dc.contributor.authorWITTFELD, Katharina
dc.contributor.authorGRABE, Hans J
dc.contributor.authorMOSLEY, Thomas H Jr
dc.contributor.authorPSATY, Bruce M
dc.contributor.authorWOLTERS, Frank J
dc.contributor.authorSESHADRI, Sudha
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDUFOUIL, Carole
dc.date.accessioned2025-05-27T13:12:28Z
dc.date.available2025-05-27T13:12:28Z
dc.date.issued2025-04-01
dc.identifier.issn1552-5279en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/206754
dc.description.abstractEnINTRODUCTION: To investigate the associations of education level, marital status, and physical activity with dementia risk and brain MRI markers. METHODS: Data from six community-based samples from the Cross-Cohort Collaboration Consortium were analyzed. Self-reported education level, marital status, and physical activity at age 60 to 75 years were harmonized. Subsamples of participants with brain MRI markers at time of exposure were selected. Associations with dementia risk and cross-sectional MRI markers were meta-analyzed. RESULTS: Higher education level was associated with lower dementia risk (hazard ratio [HR] = 0.65, 95% confidence interval [CI] = 0.59; 0.72 vs low level) but not significantly with brain MRI markers. Compared with being unmarried, being married was only associated with higher total brain and hippocampal volumes. Being physically active was associated with lower dementia risk (HR = 0.73, 95% CI = 0.52; 1.04), as well as larger total brain volume and smaller white matter hyperintensity volume. DISCUSSION: This study provides further evidence regarding the contribution of education level and physical activity to dementia resilience. HIGHLIGHTS: Education level, marital status, and physical activity are thought to contribute to resilience against ADRD. We used random-effects meta-analysis to summarize results from six community-based samples from the CCC. In this cross-cohort meta-analysis, higher education level and being physically active were associated with lower risk of dementia. In cross-sectional analyses, being married was associated with larger TBV and HV, while being physically active was associated with larger TBV and lower WMHV.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enMRI
dc.subject.enCohorts
dc.subject.enDementia
dc.subject.enMeta‐Analysis
dc.subject.enResilience
dc.title.enSelected social and lifestyle correlates of brain health markers: the Cross-Cohort Collaboration Consortium
dc.title.alternativeAlzheimers Dementen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/alz.70148en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed40207408en_US
bordeaux.journalAlzheimer's & Dementia : the Journal of the Alzheimer's Associationen_US
bordeaux.pagee70148en_US
bordeaux.volume21en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPHARES_BPHen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDNational Institute on Agingen_US
bordeaux.identifier.funderIDZonMwen_US
hal.identifierhal-05086909
hal.version1
hal.date.transferred2025-05-27T13:12:35Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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