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Progression of Carotid Intima-Media Thickness in Children of the Cardiovascular Comorbidity in Children With Chronic Kidney Disease Study: Risk Factors and Impact of Blood Pressure Dynamics

dc.rights.licenseopenen_US
dc.contributor.authorDOYON, Anke
dc.contributor.authorHOFSTETTER, Jonas
dc.contributor.authorBAYAZIT, Aysun Karabay
dc.contributor.authorAZUKAITIS, Karolis
dc.contributor.authorNIEMIRSKA, Ana
dc.contributor.authorCIVILIBAL, Mahmut
dc.contributor.authorKAPLAN BULUT, Ipek
dc.contributor.authorDUZOVA, Ali
dc.contributor.authorOGUZ, Berna
dc.contributor.authorRANCHIN, Bruno
dc.contributor.authorSHROFF, Rukshana
dc.contributor.authorBILGINER, Yelda
dc.contributor.authorCALISKAN, Salim
dc.contributor.authorPARIPOVIC, Dusan
dc.contributor.authorCANDAN, Cengiz
dc.contributor.authorYILMAZ, Alev
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHARAMBAT, Jerome
dc.contributor.authorOZCAKAR, Zeynep Birsin
dc.contributor.authorLUGANI, Francesca
dc.contributor.authorALPAY, Harika
dc.contributor.authorTSCHUMI, Sibylle
dc.contributor.authorYILMAZ, Ebru
dc.contributor.authorDROZDZ, Dorota
dc.contributor.authorTABEL, Yilmaz
dc.contributor.authorOZCELIK, Gul
dc.contributor.authorCALDAS AFONSO, Alberto
dc.contributor.authorYAVASCAN, Onder
dc.contributor.authorMELK, Anette
dc.contributor.authorQUERFELD, Uwe
dc.contributor.authorSCHAEFER, Franz
dc.date.accessioned2025-05-27T08:45:28Z
dc.date.available2025-05-27T08:45:28Z
dc.date.issued2025-04-01
dc.identifier.issn2047-9980en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/206739
dc.description.abstractEnBackground Carotid intima-media thickness (cIMT) may identify early alterations in the vascular phenotype in children with chronic kidney disease (CKD).Methods and Results Investigation of longitudinal changes in cIMT SD scores (SDS) in 670 patients from the 4C Study (Cardiovascular Comorbidity in Children With CKD Study), aged 6 to 17 years, with CKD stage 3 to 5 at baseline. The longitudinal trajectory of cIMT SDS over up to 8 years was examined using a longitudinal mixed-effects model. The yearly progression rate in cIMT SDS (beta=0.20 [95% CI, 0.13-0.28]) remained positive during the initial 4.5-year follow-up period but slowed down quadratically with increasing observation time (beta=-0.02 [95% CI, -0.03 to -0.01]). Risk factors for increased cIMT SDS included time since baseline, younger age, higher height SDS, female sex, elevated diastolic blood pressure, and lower serum albumin, but not estimated glomerular filtration rate. In patients with progressive CKD, higher albuminuria was additionally associated with an increase in cIMT SDS. In patients with stable CKD, serum phosphate and time were the only risk factors identified for elevated cIMT SDS. Annual rates of change in blood pressure were positively correlated with the rate of change in cIMT SDS within the first 4.5 years (for systolic: beta=0.42 [95% CI, 0.22-0.62]; for diastolic: beta=1.56 [95% CI, 1.01-2.11]).Methods and Results Investigation of longitudinal changes in cIMT SD scores (SDS) in 670 patients from the 4C Study (Cardiovascular Comorbidity in Children With CKD Study), aged 6 to 17 years, with CKD stage 3 to 5 at baseline. The longitudinal trajectory of cIMT SDS over up to 8 years was examined using a longitudinal mixed-effects model. The yearly progression rate in cIMT SDS (beta=0.20 [95% CI, 0.13-0.28]) remained positive during the initial 4.5-year follow-up period but slowed down quadratically with increasing observation time (beta=-0.02 [95% CI, -0.03 to -0.01]). Risk factors for increased cIMT SDS included time since baseline, younger age, higher height SDS, female sex, elevated diastolic blood pressure, and lower serum albumin, but not estimated glomerular filtration rate. In patients with progressive CKD, higher albuminuria was additionally associated with an increase in cIMT SDS. In patients with stable CKD, serum phosphate and time were the only risk factors identified for elevated cIMT SDS. Annual rates of change in blood pressure were positively correlated with the rate of change in cIMT SDS within the first 4.5 years (for systolic: beta=0.42 [95% CI, 0.22-0.62]; for diastolic: beta=1.56 [95% CI, 1.01-2.11]).Conclusions The results show a significant longitudinal increase in cIMT SDS in children with CKD. Changes in blood pressure are associated with the progression of cIMT SDS, suggesting a relevant impact of blood pressure modulation on cIMT SDS.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enCardiovascular Disease
dc.subject.enCarotid Intima‐Media Thickness
dc.subject.enChronic Kidney Disease
dc.subject.enHypertension
dc.subject.enPediatric
dc.title.enProgression of Carotid Intima-Media Thickness in Children of the Cardiovascular Comorbidity in Children With Chronic Kidney Disease Study: Risk Factors and Impact of Blood Pressure Dynamics
dc.title.alternativeJ Am Heart Assocen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1161/jaha.124.037563en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed40135569en_US
bordeaux.journalJournal of the American Heart Associationen_US
bordeaux.pagee037563en_US
bordeaux.volume14en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDEuropean Renal Association-European Dialysis and Transplant Associationen_US
hal.identifierhal-05086295
hal.version1
hal.date.transferred2025-05-27T08:45:33Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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