Classical psychedelics’ action on brain monoaminergic systems
| dc.rights.license | open | en_US |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | BUTLER, Jasmine Jade | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | RICCI, Daria | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | AMAN, Chloé | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | BEYELER, Anna
ORCID: 0000-0003-2371-5706 IDREF: 141902892 | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | DE DEURWAERDÈRE, Philippe | |
| dc.date.accessioned | 2025-05-23T08:34:13Z | |
| dc.date.available | 2025-05-23T08:34:13Z | |
| dc.date.issued | 2024-11 | |
| dc.identifier.issn | 1357-2725 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/206693 | |
| dc.description.abstractEn | The study of the mechanism of action of classical psychedelics has gained significant interest due to their clinical potential in the treatment of several psychiatric conditions, including major depressive and anxiety disorders. These drugs bind 5-hydroxytryptamine receptors (5-HTR) including 5-HT1AR, 5-HT2AR, 5-HT2BR, and/or 5-HT2CR, as well as other targets. 5-HTRs regulate the activity of ascending monoaminergic neurons, a mechanism primarily involved in the action of classical antidepressant drugs, antipsychotics, and drugs of abuse. Sparse neurochemical data have been produced on the control of monoaminergic neuron activity in response to classical psychedelics. Here we review the available data in order to determine whether classical psychedelics have specific neurochemical effects on serotonergic, dopaminergic, and noradrenergic neurons. The data show that these drugs have disparate effects on each monoaminergic system, demonstrating a complex response with state-dependent and region-specific effects. For instance, several psychedelics inhibit the firing of serotonergic neurons, although this is not necessarily associated with a decrease in serotonin release in all regions. Noradrenergic neuron spontaneous activity also appears to be inhibited by psychedelics, also not necessarily associated with a decrease in noradrenaline release in all regions. Psychedelics influence on dopaminergic systems is also complex as the above-mentioned 5-HTRs may have opposing effects on dopaminergic neuron activity, in a state-dependent manner. There is an apparent lack of clear neuronal signature induced by psychedelics on monoaminergic neuron activity despite specific recurrent mechanisms. This review provides a current summary of the action of psychedelics on monoamine neuromodulators serotonin, dopamine and noradrenaline, compiling reoccurring and contradictory findings demonstrating that a monoamine signature of psychedelics, if applicable, would be state- and region-dependant. © 2024 Elsevier Ltd | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Serotonin | |
| dc.subject.en | Dopamine | |
| dc.subject.en | Noradrenaline | |
| dc.subject.en | Psychedelics | |
| dc.subject.en | Microdialysis | |
| dc.subject.en | Single-cell extracellular recordings | |
| dc.subject.en | Serotonin receptors | |
| dc.title.en | Classical psychedelics’ action on brain monoaminergic systems | |
| dc.title.alternative | Int J Biochem Cell Biol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.biocel.2024.106669 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 39332625 | en_US |
| bordeaux.journal | International Journal of Biochemistry and Cell Biology | en_US |
| bordeaux.volume | 176 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | CNRS | |
| bordeaux.team | Circuits Neuronaux de l'Anxiété | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-05081379 | |
| hal.version | 1 | |
| hal.date.transferred | 2025-05-23T08:34:15Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International%20Journal%20of%20Biochemistry%20and%20Cell%20Biology&rft.date=2024-11&rft.volume=176&rft.eissn=1357-2725&rft.issn=1357-2725&rft.au=BUTLER,%20Jasmine%20Jade&RICCI,%20Daria&AMAN,%20Chlo%C3%A9&BEYELER,%20Anna&DE%20DEURWAERD%C3%88RE,%20Philippe&rft.genre=article |
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