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Cannabinoids regulate an insula circuit controlling water intake

dc.rights.licenseopenen_US
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorZHAO, Zhe
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCOVELO, Ana
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMITRA, Arojit
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorVARILH, Marjorie
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorWU, Yifan
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorJACKY, Débora
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCANNICH, Astrid
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorBELLOCCHIO, Luigi
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMARSICANO, Giovanni
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorBEYELER, Anna
dc.date.accessioned2025-05-19T08:35:54Z
dc.date.available2025-05-19T08:35:54Z
dc.date.created2024-05-06
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/206647
dc.description.abstractEnThe insular cortex, or insula, is a large brain region involved in the detection of thirst and the regulation of water intake. However, our understanding of the topographical, circuit, and molecular mechanisms for controlling water intake within the insula remains parcellated. We found that type-1 cannabinoid (CB1) receptors in the insular cortex cells participate in the regulation of water intake and deconstructed the circuit mechanisms of this control. Topographically, we revealed that the activity of excitatory neurons in both the anterior insula (aIC) and posterior insula (pIC) increases in response to water intake, yet only the specific removal of CB1 receptors in the pIC decreases water intake. Interestingly, we found that CB1 receptors are highly expressed in insula projections to the basolateral amygdala (BLA), while undetectable in the neighboring central part of the amygdala. Thus, we recorded the neurons of the aIC or pIC targeting the BLA (aIC-BLA and pIC-BLA) and found that they decreased their activity upon water drinking. Additionally, chemogenetic activation of pIC-BLA projection neurons decreased water intake. Finally, we uncovered CB1-dependent short-term synaptic plasticity (depolarization-induced suppression of excitation [DSE]) selectively in pIC-BLA, compared with aIC-BLA synapses. Altogether, our results support a model where CB1 receptor signaling promotes water intake by inhibiting the pIC-BLA pathway, thereby contributing to the fine top-down control of thirst responses. © 2024 Elsevier Inc.
dc.description.sponsorshipDéveloppment d'une infrastructure française distribuée coordonnéeen_US
dc.description.sponsorshipDissection des mécanismes hypothalamiques impliqués dans la détection du statut nutritionnel et régulation de la prise alimentaire via les interactions entre mTORC1, les mélanocortines et les endocannabinoïdes.en_US
dc.description.sponsorshipReprésentation sensorielle lors d'états psychotiquesen_US
dc.description.sponsorshipRecepteurs aux cannabinoides dans le codage visuel cortical - ANR-18-CE16-0001en_US
dc.language.isoENen_US
dc.subject.enInsular circuits
dc.subject.enBLA
dc.subject.enNeural activity
dc.subject.enCB1 receptor
dc.subject.enDepolarization-33 induced suppression of excitation
dc.subject.enWater intake
dc.title.enCannabinoids regulate an insula circuit controlling water intake
dc.typeDocument de travail - Pré-publicationen_US
dc.identifier.doi10.1016/j.cub.2024.03.053en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed38636514en_US
dc.description.sponsorshipEuropeNeurocircuitry of endocannabinoid regulation of food intakeen_US
dc.description.sponsorshipEuropeDevelopment of pregnenolone derivatives as allosteric inhibitors of CB1 cannabinoid receptors for thetreatment of schizophrenia and psychotic syndromesen_US
dc.description.sponsorshipEuropeMitochondrial Cannabinoid Receptors in the Brainen_US
bordeaux.journalCurrent Biologyen_US
bordeaux.page1918 – 1929en_US
bordeaux.volume34en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEndocannabinoïdes et Neuroadaptationen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
hal.identifierhal-05072881
hal.version1
hal.date.transferred2025-05-19T08:35:59Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.subtypePrepublication/Preprinten_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Current%20Biology&rft.volume=34&rft.issue=9&rft.spage=1918%20%E2%80%93%201929&rft.epage=1918%20%E2%80%93%201929&rft.au=ZHAO,%20Zhe&COVELO,%20Ana&MITRA,%20Arojit&VARILH,%20Marjorie&WU,%20Yifan&rft.genre=preprint


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