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Associations between agricultural use of pyrethroid insecticides and asthma: AGRICAN cohort results

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBALDI, Isabelle
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDE GRAAF, Lucie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBUREAU, Mathilde
dc.contributor.authorTUAL, Severine
dc.contributor.authorDOUWES, Jeroen
dc.contributor.authorLEBAILLY, Pierre
dc.date.accessioned2025-05-16T07:52:00Z
dc.date.available2025-05-16T07:52:00Z
dc.date.issued2025-04-10
dc.identifier.issn0013-9351en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/206639
dc.description.abstractEnRATIONALE: Following the withdrawal of organochlorines and organophosphates, pyrethroids have become the most used insecticides in both agricultural and domestic settings. OBJECTIVES: We analyzed data from the French AGRICAN agricultural cohort to assess associations of occupational pyrethroid exposures and allergic/non-allergic asthma. METHODS: At enrollment, asthma diagnosed by a doctor was reported by 11 815 participants (7028 classified as non-allergic and 4458 as allergic based on the presence of eczema and/or hay fever). Individual exposures to 17 pyrethroids were defined in 124 992 participants, based on a combination of the history of pesticide treatment of 11 crops (grassland, vineyard, wheat/barley, corn, field peas, potatoes, tobacco, beets, sunflower, rape, fruits) and a crop-exposure matrix. MEASUREMENTS AND MAIN RESULTS: In men, no association was observed for any of the pyrethroids regardless of asthma phenotype. In contrast, in ever-exposed women, asthma risk was increased with use of any pyrethroid, both for allergic (+80 %) and non-allergic asthma (+40 %). Highest increases were observed for allergic asthma with fenpropathrin (OR = 2.00; 95 %CI:1.38-2.90), tralomethrin (OR = 1.81; 95 %CI:1.28-2.56), fenvalerate (OR = 1.81; 95 %CI:1.38-2.38), permethrin (OR = 1.78; 95 %CI:1.26-2.50) and deltamethrin (OR = 1.76; 95 %CI:1.35-2.29). Stratified analyses on women who reported living on a farm in early life showed stronger associations for non-allergic asthma. For women who reported early life living on vineyards associations with pyrethroids were stronger for both allergic and non-allergic asthma. Associations for women who lived on cattle farms were reduced for some pyrethroids. CONCLUSION: Occupational pyrethroid exposure was positively associated with both allergic and non-allergic asthma in women but not in men.
dc.language.isoENen_US
dc.subject.enAgricultural exposure
dc.subject.enAllergy
dc.subject.enAsthma
dc.subject.enPesticides
dc.subject.enPyrethroids
dc.title.enAssociations between agricultural use of pyrethroid insecticides and asthma: AGRICAN cohort results
dc.title.alternativeEnviron Resen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.envres.2025.121583en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed40220893en_US
bordeaux.journalEnvironmental Researchen_US
bordeaux.page121583en_US
bordeaux.volume277en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-05070206
hal.version1
hal.date.transferred2025-05-16T07:52:02Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Environmental%20Research&rft.date=2025-04-10&rft.volume=277&rft.spage=121583&rft.epage=121583&rft.eissn=0013-9351&rft.issn=0013-9351&rft.au=BALDI,%20Isabelle&DE%20GRAAF,%20Lucie&BUREAU,%20Mathilde&TUAL,%20Severine&DOUWES,%20Jeroen&rft.genre=article


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