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Identification and evolution of rickets and scurvy therapeutics between the 17th and 19th centuries CE: archaeo- and palaeopharmacological approach

hal.structure.identifierArchéosciences Bordeaux
dc.contributor.authorZINN, Alexandra
hal.structure.identifierInstitut national de recherches archéologiques préventives - Centre archéologique de Grand-Quevilly [Inrap, Grand-Quevilly]
hal.structure.identifierCentre Michel de Boüard - Centre de recherches archéologiques et historiques anciennes et médiévales [CRAHAM]
dc.contributor.authorTHOMANN, Aminte
hal.structure.identifierArchéosciences Bordeaux
dc.contributor.authorLEFRAIS, Yannick
hal.structure.identifierArchéosciences Bordeaux
dc.contributor.authorPIANET, Isabelle
hal.structure.identifierÉcole Pratique des Hautes Études [EPHE]
hal.structure.identifierArchéosciences Bordeaux
dc.contributor.authorCOLOMBO, Antony
dc.date.accessioned2025-05-13T02:00:59Z
dc.date.available2025-05-13T02:00:59Z
dc.date.conference2024-11-20
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/206602
dc.description.abstractEnIn France, the industrialisation period has seen a number of economic and social transitions. The epidemiological transition experienced during this time led to the emergence of diseases linked to this specific context (e.g. respiratory and cardiovascular diseases) and modifications in the prevalence of deficiency diseases such as rickets (vitamin D) and scurvy (vitamin C). However, it was also a period of major scientific progresses, particularly in medicine and pharmacy. As a result, treatments for deficiency diseases have changed. An exhaustive review of these treatments in the medico-historical literature (medical treatises and theses, ancient pharmacopoeia, archives) has enabled us to identify both plant-based (including for example rhubarb, opium, cinchona) and animal-based treatments (e.g. after 1850, cod liver oil, the only effective treatment against rickets) or treatments containing metal elements, particularly mercury. The latter is now recognised as extremely toxic, but has been widely used in many forms for medical purposes since the 17th century. We present here the results obtained on the individual SP5 from the Rue Thubeuf cemetery (Rouen, late 18-19th centuries, France), a 3-4-year-old child showing signs of multiple bone deficiencies, probably rickets and scurvy. Bone and tooth samples from SP5 have been analysed through a palaeopharmacological approach, using an archaeometric strategy in three stages to: 1- detect mercury (X-ray fluorescence), 2- quantify it (CV-AAS) and 3- localise it in the mineral matrix (LIBS). The ED-XRF spectrum of the bone sample revealed a mercury peak, absent in the dental sample and the CV-AAS analysis showed a high concentration of mercury in the bone (9.373 mg/kg ± 10% uncertainty). This preliminary archaeometric study revealed an abnormal concentration of mercury, suggesting a potential severe ante mortem intoxication. The potential sources of contamination have been discussed and ruled out, reinforcing the hypothesis of mercurial treatment.
dc.language.isoen
dc.title.enIdentification and evolution of rickets and scurvy therapeutics between the 17th and 19th centuries CE: archaeo- and palaeopharmacological approach
dc.typeAutre communication scientifique (congrès sans actes - poster - séminaire...)
dc.subject.halSciences de l'Homme et Société/Anthropologie biologique
bordeaux.hal.laboratoriesArchéosciences Bordeaux - UMR 6034*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionUniversité Bordeaux Montaigne
bordeaux.institutionCNRS
bordeaux.conference.title16th Annual Meeting of the SSCIP
bordeaux.countryFR
bordeaux.conference.cityBordeaux
bordeaux.peerReviewedoui
hal.identifierhal-05064643
hal.version1
hal.invitednon
hal.proceedingsnon
hal.conference.organizerSociety for the Study of the Childhood in the Past
hal.conference.end2024-11-23
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-05064643v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.au=ZINN,%20Alexandra&THOMANN,%20Aminte&LEFRAIS,%20Yannick&PIANET,%20Isabelle&COLOMBO,%20Antony&rft.genre=conference


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