Asbestos exposure, pleural plaques and digestive cancers
| dc.rights.license | open | en_US |
| dc.contributor.author | CLIN, Benedicte | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | GRAMOND, Celine | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DELVA, Fleur | |
| dc.contributor.author | ANDUJAR, Pascal | |
| dc.contributor.author | THAON, Isabelle | |
| dc.contributor.author | BROCHARD, Patrick | |
| dc.contributor.author | BENOIST, Julia | |
| dc.contributor.author | GISLARD, Antoine | |
| hal.structure.identifier | Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB] | |
| dc.contributor.author | LAURENT, Francois | |
| hal.structure.identifier | Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB] | |
| dc.contributor.author | BENLALA, Ilyes | |
| dc.contributor.author | PARIS, Christophe | |
| dc.contributor.author | PAIRON, Jean-Claude | |
| dc.date.accessioned | 2025-05-07T08:29:08Z | |
| dc.date.available | 2025-05-07T08:29:08Z | |
| dc.date.issued | 2025-02-19 | |
| dc.identifier.issn | 1471-2458 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/206569 | |
| dc.description.abstractEn | BackgroundThe aim of this study was to analyse the incidence and mortality from various digestive cancer sites and their potential link with pleural plaques, in a French cohort of workers previously occupationally exposed to asbestos.MethodsWe conducted a 10-year follow-up study in 13,481 male subjects, included in the cohort between October 2003 and December 2005, for whom asbestos exposure was assessed by calculation of a cumulative exposure index (CEI) in equivalent fibres.years/mL for each subject. We conducted an incidence study and a mortality study. Complementary analysis was restricted to men who had performed at least one chest CT-scan (N = 4,794). We used a Cox model with age as the time axis variable, adjusted for smoking, time since first exposure (TSFE), CEI to asbestos and the existence of pleural plaques on CT-scan.ResultsIn the incidence study, a significant dose-response relationship was observed between CEI to asbestos and oesophageal cancer (HR 1.03, 95% CI [1.01-1.06]) in the entire cohort after adjustment for TSFE and smoking status. In subjects undergoing CT-scan, a significant association between pleural plaques was observed for oesophageal cancer incidence (HR 2.80, 95% CI [1.09-7.20]) and in the mortality study, multivariate analyses showed a significant dose-effect response between CEI to asbestos and death from oesophageal cancer (HR 1.03, 95% CI [1.00-1.05]) in the entire cohort.ConclusionsThis large-scale study confirms results concerning a likely relationship between asbestos exposure and oesophageal cancer, and the association between this cancer and pleural plaques after adjustment on CEI to asbestos. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject.en | Asbestos | |
| dc.subject.en | Cancer | |
| dc.subject.en | Digestive cancer | |
| dc.subject.en | Incidence | |
| dc.subject.en | Mortality | |
| dc.subject.en | Occupational exposure | |
| dc.subject.en | Oesophageal cancer | |
| dc.subject.en | Pleural plaque | |
| dc.title.en | Asbestos exposure, pleural plaques and digestive cancers | |
| dc.title.alternative | BMC Public Health | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1186/s12889-025-21969-0 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 39972315 | en_US |
| bordeaux.journal | BMC Public Health | en_US |
| bordeaux.page | 686 | en_US |
| bordeaux.volume | 25 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | EPICENE_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail | en_US |
| bordeaux.identifier.funderID | Ministère du Travail, de l’Emploi, de la Formation Professionnelle et du Dialogue Social | en_US |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
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