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Evaluation of adherence patterns in schizophrenia using electronic monitoring (MEMS®): A six-month post-discharge prospective study

dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorMISDRAHI, David
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorTESSIER, Arnaud
hal.structure.identifierLaboratoire de psychologie [LabPsy]
dc.contributor.authorHUSKY, Mathilde
IDREF: 079957668
dc.contributor.authorLANGE, Anne-Catherine
dc.contributor.authorVRIJENS, Bernard
dc.contributor.authorLLORCA, Pierre-Michel
dc.contributor.authorBAYLE, Franck
dc.date.accessioned2025-05-05T10:00:07Z
dc.date.available2025-05-05T10:00:07Z
dc.date.issued2018-03
dc.identifier.issn1573-2509en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/206544
dc.description.abstractEnBackground: Medication Event Monitoring System (MEMS®) is considered the gold standard for the evaluation of medication adherence, yet few studies have applied this method, especially over long periods of time. Objective: To investigate medication adherence patterns in a sample of post-discharge patients with schizophrenia monitored with MEMS caps during a six-month period. Method: Adherence to antipsychotics was prospectively investigated using MEMS among 68 patients with schizophrenia. Treatment initiation, implementation or whether or not the patient takes his dosing regimen as prescribed, persistence or the length of time between initiation and discontinuation, and treatment discontinuation were used to describe adherence. Persistence over time was described using Kaplan-Meier curves. Results: After discharge 16% of the patients never initiated treatment. On average 37.3% of patients adhered to treatment in the first 6months. However, a strong decrease in adherence was observed over time (p<0.0001), primarily due by treatment non-persistence. Only half of the patients were persistent at 6weeks, persistence further dropped to 19.0% after 6months. Among persistent patients, implementation was consistent over time with 87.8% of patients taking their medication as prescribed on any given day. Conclusions: Dosing profile analysis provides further evidence for the magnitude of non-adherence with antipsychotic prescriptions among post-discharge patients with schizophrenia. Using the high precision of MEMS®, dosing profiles may provide a better understanding of non-adherence patterns and help clinicians determine optimal individualized strategies.
dc.language.isoENen_US
dc.subject.enElectronic monitoring
dc.subject.enMedication adherence
dc.subject.enMedication event monitoring system
dc.subject.enNon-adherence
dc.subject.enSchizophrenia
dc.title.enEvaluation of adherence patterns in schizophrenia using electronic monitoring (MEMS®): A six-month post-discharge prospective study
dc.title.alternativeSchizophr Resen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.schres.2017.06.026en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed28663027en_US
bordeaux.journalSchizophrenia Researchen_US
bordeaux.page114-118en_US
bordeaux.volume193en_US
bordeaux.hal.laboratoriesInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDMinistère de la Santéen_US
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hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
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dc.rights.ccPas de Licence CCen_US
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