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Acute Clinical Events Identified as Relapses With Stable Magnetic Resonance Imaging in Multiple Sclerosis

dc.rights.licenseopenen_US
dc.contributor.authorGAVOILLE, Antoine
dc.contributor.authorROLLOT, Fabien
dc.contributor.authorCASEY, Romain
dc.contributor.authorKERBRAT, Anne
dc.contributor.authorLE PAGE, Emmanuelle
dc.contributor.authorBIGAUT, Kevin
dc.contributor.authorMATHEY, Guillaume
dc.contributor.authorMICHEL, Laure
dc.contributor.authorCIRON, Jonathan
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorRUET, Aurelie
dc.contributor.authorMAILLART, Elisabeth
dc.contributor.authorLABAUGE, Pierre
dc.contributor.authorZEPHIR, Hélène
dc.contributor.authorPAPEIX, Caroline
dc.contributor.authorDEFER, Gilles
dc.contributor.authorLEBRUN-FRENAY, Christine
dc.contributor.authorMOREAU, Thibault
dc.contributor.authorBERGER, Eric
dc.contributor.authorSTANKOFF, Bruno
dc.contributor.authorCLAVELOU, Pierre
dc.contributor.authorTHOUVENOT, Eric
dc.contributor.authorHEINZLEF, Olivier
dc.contributor.authorPELLETIER, Jean
dc.contributor.authorAL-KHEDR, Abdullatif
dc.contributor.authorCASEZ, Olivier
dc.contributor.authorBOURRE, Bertrand
dc.contributor.authorCABRE, Philippe
dc.contributor.authorWAHAB, Abir
dc.contributor.authorMAGY, Laurent
dc.contributor.authorCAMDESSANCHÉ, Jean-Philippe
dc.contributor.authorDOGHRI, Inès
dc.contributor.authorMOULIN, Solène
dc.contributor.authorBEN-NASR, Haifa
dc.contributor.authorLABEYRIE, Céline
dc.contributor.authorHANKIEWICZ, Karolina
dc.contributor.authorNEAU, Jean-Philippe
dc.contributor.authorPOTTIER, Corinne
dc.contributor.authorNIFLE, Chantal
dc.contributor.authorMANCHON, Eric
dc.contributor.authorLAPERGUE, Bertrand
dc.contributor.authorWIERTLEWSKI, Sandrine
dc.contributor.authorDE SÈZE, Jérôme
dc.contributor.authorVUKUSIC, Sandra
dc.contributor.authorLAPLAUD, David Axel
dc.contributor.authorCOTTON, François
dc.contributor.authorDOUEK, Pascal
dc.contributor.authorGUILLEMIN, Francis
dc.contributor.authorPACHOT, Alexandre
dc.contributor.authorOLAIZ, Javier
dc.contributor.authorRIGAUD-BULLY, Claire
dc.contributor.authorMARIGNIER, Romain
dc.contributor.authorMATHEY, Guillaume
dc.contributor.authorKERBRAT, Anne
dc.contributor.authorBIOTTI, Damien
dc.contributor.authorOUALLET, Jean-Christophe
dc.contributor.authorCOLLONGUES, Nicolas
dc.contributor.authorOUTTERYCK, Olivier
dc.contributor.authorMOISSET, Xavier
dc.contributor.authorDERACHE, Nathalie
dc.contributor.authorCOHEN, Mikaël
dc.contributor.authorFROMONT, Agnès
dc.contributor.authorWIERTLEWSKY, Sandrine
dc.contributor.authorBEREAU, Matthieu
dc.contributor.authorAUDOIN, Bertrand
dc.contributor.authorGIANNESINI, Claire
dc.contributor.authorBENSA, Caroline
dc.contributor.authorCASTELNOVO, Giovanni
dc.contributor.authorFAGNIEZ, Ombeline
dc.contributor.authorHEBANT, Benjamin
dc.contributor.authorVAILLANT, Mathieu
dc.contributor.authorJEANIN, Séverine
dc.contributor.authorCRÉANGE, Alain
dc.contributor.authorVALLAT, Jean-Michel
dc.contributor.authorCONVERS, Philippe
dc.contributor.authorBELTRAN, Stéphane
dc.contributor.authorLABEYRIE, Céline
dc.contributor.authorHENRY, Carole
dc.contributor.authorCAMUZEAUX, Marie
dc.contributor.authorDELATTRE, Maryline
dc.contributor.authorTROTTA, Laura
dc.contributor.authorGIROD, Catherine
dc.contributor.authorOSTERMANN-ZIEGLER, Amandine
dc.contributor.authorLE PORT, Damien
dc.contributor.authorFREITAS, Noellie
dc.contributor.authorBERTHE, Carole
dc.contributor.authorLATASTE, Katy-Kim
dc.contributor.authorZEHROUNI, Karima
dc.contributor.authorPINNA, Frédéric
dc.contributor.authorPETIT, Julie
dc.contributor.authorSAFA DIALLO, Sadou
dc.contributor.authorDROULON, Karine
dc.contributor.authorCALLIER, Céline
dc.contributor.authorPROTIN, Alexia
dc.contributor.authorMOYON, Melinda
dc.contributor.authorCAPPE, Chrystelle
dc.contributor.authorDUMONT, Emilie
dc.contributor.authorAGHERBI, Hanane
dc.contributor.authorBLANCHERE, Marie
dc.contributor.authorRANJEVA, Marie-Pierre
dc.contributor.authorDA VEIGA, Amandine
dc.contributor.authorDIOP KANE, Maty
dc.contributor.authorVIMONT, Christine
dc.contributor.authorCAYOL, Marjory
dc.contributor.authorBALDE, Safiyatou
dc.contributor.authorROUSSEAU, Daisy
dc.contributor.authorFERRAUD, Karine
dc.contributor.authorMEUNIER, Géraldine
dc.contributor.authorVARNIER, Elise
dc.contributor.authorLESCIEUX, Edwige
dc.contributor.authorBOURENANE, Halima
dc.contributor.authorCOSSEC, Stéphanie
dc.contributor.authorRABOIS, Emilie
dc.contributor.authorBENAMMAR, Lynda
dc.contributor.authorBEULAYGUE, Anaïs
dc.date.accessioned2025-04-29T13:07:23Z
dc.date.available2025-04-29T13:07:23Z
dc.date.issued2024-08
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/206485
dc.description.abstractEnIMPORTANCE Understanding the association between clinically defined relapses and radiological activity in multiple sclerosis (MS) is essential for patient treatment and therapeutic development. OBJECTIVE To investigate clinical events identified as relapses but not associated with new T2 lesions or gadolinium-enhanced T1 lesions on brain and spinal cord magnetic resonance imaging (MRI). DESIGN, SETTING, AND PARTICIPANTS This multicenter observational cohort study was conducted between January 2015 and June 2023. Data were extracted on June 8, 2023, from the French MS registry. All clinical events reported as relapses in patients with relapsing-remitting MS were included if brain and spinal cord MRI was performed within 12 and 24 months before the event, respectively, and 50 days thereafter with gadolinium injection. EXPOSURES Events were classified as relapses with active MRI (RAM) if a new T2 lesion or gadolinium-enhanced T1 lesion appeared on brain or spinal cord MRI or as acute clinical events with stable MRI (ACES) otherwise. MAIN OUTCOMES AND MEASURES Factors associated with ACES were investigated; patients with ACES and RAM were compared regarding Expanded Disability Status Scale (EDSS) course, relapse rate, confirmed disability accrual (CDA), relapse-associated worsening (RAW), progression independent of relapse activity (PIRA), and transition to secondary progressive (SP) MS, and ACES and RAM rates under each disease-modifying therapy (DMT) were estimated. RESULTS Among 31 885 clinical events, 637 in 608 patients (493 [77.4%] female; mean [SD] age, 35.8 [10.7] years) were included. ACES accounted for 166 (26.1%) events and were more likely in patients receiving highly effective DMTs, those with longer disease duration (odds ratio [OR], 1.04; 95% CI, 1.01-1.07), or those presenting with fatigue (OR, 2.14; 95% CI, 1.15-3.96). ACES were associated with significant EDSS score increases, lower than those found for RAM. Before the index event, patients with ACES experienced significantly higher rates of relapse (relative rate [RR], 1.21; 95% CI, 1.01-1.46), CDA (hazard ratio [HR], 1.54; 95% CI, 1.13-2.11), and RAW (HR, 1.72; 95% CI, 1.20-2.45). Patients with ACES were at significantly greater risk of SP transition (HR, 2.58; 95% CI, 1.02-6.51). Although RAM rate decreased with DMTs according to their expected efficacy, ACES rate was stable across DMTs. CONCLUSIONS AND RELEVANCE The findings in this study introduce the concept of ACES in MS, which accounted for one-fourth of clinical events identified as relapses. © 2024 American Medical Association. All rights reserved.
dc.language.isoENen_US
dc.title.enAcute Clinical Events Identified as Relapses With Stable Magnetic Resonance Imaging in Multiple Sclerosis
dc.title.alternativeJAMA Neurolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1001/jamaneurol.2024.1961en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed38949816en_US
bordeaux.journalJAMA neurologyen_US
bordeaux.page814-823en_US
bordeaux.volume81en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue8en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamRelations glie-neuroneen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=JAMA%20neurology&rft.date=2024-08&rft.volume=81&rft.issue=8&rft.spage=814-823&rft.epage=814-823&rft.au=GAVOILLE,%20Antoine&ROLLOT,%20Fabien&CASEY,%20Romain&KERBRAT,%20Anne&LE%20PAGE,%20Emmanuelle&rft.genre=article


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