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Deciphering HIV vaccine-induced Antibody response according to ethnicity

dc.rights.licenseopenen_US
dc.contributor.authorLIN, Li-Yun
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFERTE, Thomas
dc.contributor.authorCHACHAGE, Mkunde
dc.contributor.authorCASTEANO, Celso
dc.contributor.authorLAUMOND, Geraldine
dc.contributor.authorSCHMIDT, Sylvie
dc.contributor.authorTAHAR, Ouria
dc.contributor.authorCARAPITO, Raphael
dc.contributor.authorBEKKER, Linda-Gail
dc.contributor.authorCHURCHYARD, Gavin
dc.contributor.authorKEEFER, Michael
dc.contributor.authorMOODIE, Zoe
dc.contributor.authorVIEGAS, Edna
dc.contributor.authorGELDMACHER, Christof
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLHOMME, Edouard
dc.contributor.authorMOOG, Christiane
dc.date.accessioned2025-04-18T07:18:28Z
dc.date.available2025-04-18T07:18:28Z
dc.date.issued2025-03-31
dc.identifier.issn1473-5571en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/206260
dc.description.abstractEnOBJECTIVE: One recurrent question is whether an HIV-1 preventive vaccine requires adaptation to geographic and/or ethnicity background. A recent attempt to improve the Thai RV144 vaccine efficacy in South Africa resulted in non-efficacy. The potential reasons for this disappointing outcome are probably multifactorial; the role of ethnicity could not be investigated given the trials' demographics. DESIGN: To assess the role of ethnicity in the immune responses induced in HIV vaccine trials, we considered the HVTN 204 vaccine trial, which was conducted in the USA and South Africa. METHODS: Univariate and multivariate analysis of antibody responses were conducted to assess ethnicity, geographic location, Fc-receptor polymorphism, sex at birth, age and geographic location. RESULTS: We found that Black South Africans displayed higher total Immunoglobulins compared to White Americans. Noteworthy, Black South Africans showed lower HIV-specific binding IgG following vaccination. As they also showed lower background at baseline, differences between ethnic groups were narrowed after baseline background subtraction, referred to as delta values for the vaccine response outcome. CONCLUSIONS: The observed modifications of HIV-specific Ab immune responses to the HVTN 204 vaccine according to genetic, geographic location and ethnic background warrants further investigation. Additional studies of immunological differences, especially with vaccine platforms inducing high HIV-specific antibodies that correlate with vaccine efficacy may help decipher the impact of ethnicity on HIV-vaccine efficacy.
dc.language.isoENen_US
dc.title.enDeciphering HIV vaccine-induced Antibody response according to ethnicity
dc.title.alternativeAidsen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/qad.0000000000004196en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed40162984en_US
bordeaux.journalAIDS. Official journal of the international AIDS Societyen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionINRIAen_US
bordeaux.teamSISTM_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-05039069
hal.version1
hal.date.transferred2025-04-18T07:18:32Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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