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dc.rights.licenseopenen_US
dc.contributor.authorCOUVY-DUCHESNE, Baptiste
dc.contributor.authorFROUIN, Vincent
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBOUTELOUP, Vincent
dc.contributor.authorKOUSSIS, Nikitas
dc.contributor.authorSIDORENKO, Julia
dc.contributor.authorJIANG, Jiyang
dc.contributor.authorWINK, Alle Meije
dc.contributor.authorLORENZINI, Luigi
dc.contributor.authorBARKHOF, Frederik
dc.contributor.authorTROLLOR, Julian N
dc.contributor.authorMANGIN, Jean-Francois
dc.contributor.authorSACHDEV, Perminder S
dc.contributor.authorBRODATY, Henry
dc.contributor.authorLUPTON, Michelle K
dc.contributor.authorBREAKSPEAR, Michael
dc.contributor.authorCOLLIOT, Olivier
dc.contributor.authorVISSCHER, Peter M
dc.contributor.authorWRAY, Naomi R
dc.contributor.authorALZHEIMER'S DISEASE NEUROIMAGING, Initiative
dc.contributor.authorAUSTRALIAN IMAGING, Biomarkers
dc.contributor.authorLIFESTYLE FLAGSHIP STUDY OF, Ageing
dc.contributor.authorALZHEIMER'S DISEASE REPOSITORY WITHOUT BORDERS, Investigators
dc.contributor.authorGROUP, Memento Cohort Study
dc.date.accessioned2025-04-14T11:27:08Z
dc.date.available2025-04-14T11:27:08Z
dc.date.issued2025-02-01
dc.identifier.issn1097-0193en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/206181
dc.description.abstractEnAlzheimer's disease (AD) brain markers are needed to select people with early-stage AD for clinical trials and as quantitative endpoint measures in trials. Using 10 clinical cohorts (N = 9140) and the community volunteer UK Biobank (N = 37,664) we performed region of interest (ROI) and vertex-wise analyses of grey-matter structure (thickness, surface area and volume). We identified 94 trait-ROI significant associations, and 307 distinct cluster of vertex-associations, which partly overlap the ROI associations. For AD versus controls, smaller hippocampus, amygdala and of the medial temporal lobe (fusiform and parahippocampal gyri) was confirmed and the vertex-wise results provided unprecedented localisation of some of the associated region. We replicated AD associated differences in several subcortical (putamen, accumbens) and cortical regions (inferior parietal, postcentral, middle temporal, transverse temporal, inferior temporal, paracentral, superior frontal). These grey-matter regions and their relative effect sizes can help refine our understanding of the brain regions that may drive or precede the widespread brain atrophy observed in AD. An AD grey-matter score evaluated in independent cohorts was significantly associated with cognition, MCI status, AD conversion (progression from cognitively normal or MCI to AD), genetic risk, and tau concentration in individuals with none or mild cognitive impairments (AUC in 0.54-0.70, p-value < 5e-4). In addition, some of the grey-matter regions associated with cognitive impairment, progression to AD ('conversion'), and cognition/functional scores were also associated with AD, which sheds light on the grey-matter markers of disease stages, and their relationship with cognitive or functional impairment. Our multi-cohort approach provides robust and fine-grained maps the grey-matter structures associated with AD, symptoms, and progression, and calls for even larger initiatives to unveil the full complexity of grey-matter structure in AD.
dc.description.sponsorshipPaRis Artificial Intelligence Research InstitutEen_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.title.enGrey-Matter Structure Markers of Alzheimer's Disease, Alzheimer's Conversion, Functioning and Cognition: A Meta-Analysis Across 11 Cohorts
dc.title.alternativeHum Brain Mappen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/hbm.70089en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed39907291en_US
bordeaux.journalHuman Brain Mappingen_US
bordeaux.pagee70089en_US
bordeaux.volume46en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPHARES_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDSylvia and Charles Viertel Charitable Foundationen_US
bordeaux.identifier.funderIDAustralian Research Councilen_US
bordeaux.identifier.funderIDHorizon 2020en_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Human%20Brain%20Mapping&amp;rft.date=2025-02-01&amp;rft.volume=46&amp;rft.issue=2&amp;rft.spage=e70089&amp;rft.epage=e70089&amp;rft.eissn=1097-0193&amp;rft.issn=1097-0193&amp;rft.au=COUVY-DUCHESNE,%20Baptiste&amp;FROUIN,%20Vincent&amp;BOUTELOUP,%20Vincent&amp;KOUSSIS,%20Nikitas&amp;SIDORENKO,%20Julia&amp;rft.genre=article


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