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Outcomes and challenges in adolescents living with HIV in France: A nationwide cohort study over 35 years (1985-2020)

dc.rights.licenseopenen_US
dc.contributor.authorDOLLFUS, Catherine
dc.contributor.authorCHENADEC, Jerome LE
dc.contributor.authorRELIQUET, Veronique
dc.contributor.authorALBY-LAURENT, Fanny
dc.contributor.authorBREHIN, Camille
dc.contributor.authorCASERIS, Marion
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRUNEL-BELLIARD, Camille
dc.contributor.authorBLANCHE, Stephane
dc.contributor.authorWARSZAWSKI, Josiane
dc.contributor.authorFAYE, Albert
dc.contributor.authorFRANGE, Pierre
dc.contributor.authorFRENCH, Anrs- M. I. E. C. O. Study Group
dc.date.accessioned2025-04-14T08:27:23Z
dc.date.available2025-04-14T08:27:23Z
dc.date.issued2025-05-01
dc.identifier.issn1473-5571en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/206154
dc.description.abstractEnObjective: Most data published on adolescents living with HIV (ALH) have been collected before the large diffusion of second-generation integrase strand transfer inhibitors (INSTI) among the pediatric population. We analyzed the nationwide ANRS-MIE CO10 Pediatric cohort to assess the changes over time in health and social outcomes of French ALH. Design: The cohort enrolled children born in France since 1985 and, from 2005, children diagnosed with HIV at ≤13 years, including those born abroad if antiretroviral-naive at first medical care in France. Methods: Adolescents aged ≥10 years at their last visit were included in this analysis. Their characteristics were compared between three periods of birth (1985-1993, 1994-1999, 2000-2010). Results: Overall, 529 ALH were included. Their median age at first HAART initiation decreased from 94 to 29 months (p < 0·0001). At the last evaluation, the proportions of ALH receiving HAART, receiving INSTI, having HIV-RNA < 50 copies/mL and having CD4 count ≥500/μL increased over time (p < 0.0001), reaching 98·7%, 53·3%, 81·3% and 85·0%, respectively, for those born in 2000-2010. The proportion of maternal and paternal orphans decreased until 14·4% and 11·0%, respectively, for ALH born recently. Compared to middle adolescents (15-17 years) born in 1994-1999, those born in 2000-2010 demonstrated higher academic success (69·2% versus 42·3%) and less frequent academic failure (4·6% versus 6·2%). Conclusions: Despite spectacular improvement in their health and immunovirological status, ALH remain vulnerable compared to other French adolescents, with a higher risk of being orphan and/or experiencing academic failure. Specific interventions are required to improve their global quality of life. Copyright © 2025 Wolters Kluwer Health, Inc.
dc.language.isoENen_US
dc.title.enOutcomes and challenges in adolescents living with HIV in France: A nationwide cohort study over 35 years (1985-2020)
dc.title.alternativeAIDSen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/QAD.0000000000004121en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed39813288en_US
bordeaux.journalAIDS. Official journal of the international AIDS Societyen_US
bordeaux.page667-675en_US
bordeaux.volume39en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue6en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamColl_PHARES_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=AIDS.%20Official%20journal%20of%20the%20international%20AIDS%20Society&amp;rft.date=2025-05-01&amp;rft.volume=39&amp;rft.issue=6&amp;rft.spage=667-675&amp;rft.epage=667-675&amp;rft.eissn=1473-5571&amp;rft.issn=1473-5571&amp;rft.au=DOLLFUS,%20Catherine&amp;CHENADEC,%20Jerome%20LE&amp;RELIQUET,%20Veronique&amp;ALBY-LAURENT,%20Fanny&amp;BREHIN,%20Camille&amp;rft.genre=article


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